Schmidt E P, Tuder R M
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, School of Medicine.
Denver Health Medical Center, Denver, Colorado.
J Cell Death. 2010 Jul 22;3:41-53. eCollection 2010.
Apoptosis is an important contributor to the pathophysiology of lung diseases such as acute lung injury (ALI) and chronic obstructive pulmonary disease (COPD). Furthermore, the cellular environment of these acute and chronic lung diseases favors the delayed clearance of apoptotic cells. This dysfunctional efferocytosis predisposes to the release of endogenous ligands from dying cells. These so-called damage-associated molecular patterns (DAMPs) play an important role in the stimulation of innate immunity as well as in the induction of adaptive immunity, potentially against autoantigens. In this review, we explore the role of apoptosis in ALI and COPD, with particular attention to the contribution of DAMP release in augmenting the inflammatory response in these disease states.
细胞凋亡是诸如急性肺损伤（ALI）和慢性阻塞性肺疾病（COPD）等肺部疾病病理生理学的重要促成因素。此外，这些急性和慢性肺部疾病的细胞环境有利于凋亡细胞的延迟清除。这种功能失调的胞葬作用易导致死亡细胞释放内源性配体。这些所谓的损伤相关分子模式（DAMPs）在刺激先天免疫以及诱导适应性免疫（可能针对自身抗原）中起重要作用。在本综述中，我们探讨细胞凋亡在ALI和COPD中的作用，特别关注DAMP释放对增强这些疾病状态下炎症反应的贡献。
