Duyuler Pınar Türker, Duyuler Serkan, İleri Mehmet, Demir Mevlüt, Dolu Abdullah Kadir, Başyiğit Funda
Department of Cardiology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Department of Cardiology, Acıbadem Ankara Hospital, Ankara, Turkey.
J Tehran Heart Cent. 2017 Jan;12(1):6-10.
Blood viscosity and aortic sclerosis (AS) are strong predictors of cardiovascular events. The effects of blood viscosity on AS have not been studied adequately. We aimed to investigate the potential connection between whole blood viscosity (WBV) and AS. AS was detected by transthoracic echocardiography. The estimation of WBV was carried out at both high shear rate (HSR) (208/s) and low shear rate (LSR) (0.5/s) by previously validated formulae using hematocrit (HcT) and total protein (TP) in g/L. WBV at HSR (208/s) is: (0.12 × HcT) + 0.17 (TP - 2.07) and WBV at LSR (0.5/s) is: (1.89 × HcT) + 3.76 (TP - 78.42). Comparisons of WBV at both HSR and LSR were made between patients with and without AS. We included 94 patients with AS (male = 30.9%, mean age = 67.5 y) and 97 control subjects without AS (male =26.6%, mean age = 69.1 y). Almost all of the clinical, echocardiographic, and biochemical characteristics were similar, but TP values were significantly higher in the AS group than in the control group (72.9 ± 5 g/L vs. 75.8 ± 6.1 g/L; p value < 0.001). Hemoglobin and HcT levels were similar (p value = 0.604 and p value = 0.431, respectively). In the AS group, WBV at LSR and HSR was higher than that in the control group (p value = 0.001 for both LSR and HSR). In multiple stepwise logistic regression analysis, WBV was an independent predictor of AS (p value < 0.001). We found higher WBV in patients with AS than in patients without AS at both LSR (0.5/s) and HSR (208/s). WBV at both LSR and HSR was independently associated with AS.
血液黏度和主动脉硬化（AS）是心血管事件的强预测指标。血液黏度对AS的影响尚未得到充分研究。我们旨在探讨全血黏度（WBV）与AS之间的潜在联系。通过经胸超声心动图检测AS。使用血细胞比容（HcT）和每升总蛋白（TP），通过先前验证的公式在高剪切率（HSR）（208/s）和低剪切率（LSR）（0.5/s）下进行WBV估计。HSR（208/s）时的WBV为：（0.12×HcT）+0.17（TP - 2.07），LSR（0.5/s）时的WBV为：（1.89×HcT）+3.76（TP - 78.42）。对有和没有AS的患者在HSR和LSR时的WBV进行比较。我们纳入了94例AS患者（男性占30.9%，平均年龄 = 67.5岁）和97例无AS的对照受试者（男性占26.6%，平均年龄 = 69.1岁）。几乎所有临床、超声心动图和生化特征均相似，但AS组的TP值显著高于对照组（72.9±5 g/L对75.8±6.1 g/L；p值<0.001）。血红蛋白和HcT水平相似（p值分别为0.604和0.431）。在AS组中，LSR和HSR时的WBV均高于对照组（LSR和HSR的p值均为0.001）。在多步逻辑回归分析中，WBV是AS的独立预测指标（p值<0.001）。我们发现，在LSR（0.5/s）和HSR（208/s）时，AS患者的WBV均高于无AS患者。LSR和HSR时的WBV均与AS独立相关。
