Cheng P T, Grabher J J, LeGeros R Z
University of Toronto, Ont., Canada.
Magnesium. 1988;7(3):123-32.
All biological calcium phosphates form in various neutral aqueous solutions containing [CaCl2] = 1 or 3 mM, [MgCl2] = 0-9 mM, [Na2HPO4] = 0.1-90 mM and NaCl (total 300 mosM) kept quiescently at 37 degrees C for 21 days. In all solutions containing 1 mM Ca and in solutions with [Ca] = 3 mM and [PO4] less than 10 mM, heterogeneous nucleation of octa-calcium phosphate (for Mg/Ca less than or equal to 1) or brushite (for Mg/Ca greater than 1) was observed; the former transforming to apatite with time. In contrast, homogeneous nucleation of an unstable amorphous calcium magnesium phosphate occurred in solutions with [Ca] = 3 mM and [PO4] greater than or equal to 10 mM, transforming to apatite, to brushite, and to whitlockite (and newberyite) depending on Mg/Ca and [PO4] values.
所有生物磷酸钙在各种中性水溶液中形成，这些溶液含有[CaCl2]=1或3 mM、[MgCl2]=0 - 9 mM、[Na2HPO4]=0.1 - 90 mM以及NaCl（总渗透压为300 mosM），在37℃下静置21天。在所有含1 mM钙的溶液以及钙浓度为3 mM且磷酸根浓度小于10 mM的溶液中，观察到了磷酸八钙（镁钙比小于或等于时）或透钙磷石（镁钙比大于1时）的异质成核现象；前者随时间转化为磷灰石。相比之下，在钙浓度为3 mM且磷酸根浓度大于或等于10 mM的溶液中发生了不稳定的无定形磷酸钙镁的均匀成核现象，根据镁钙比和磷酸根浓度值，其会转化为磷灰石、透钙磷石以及白磷钙矿（和新磷钙石）。
