Pedersen Maria, Ekstedt Mirjam, Småstuen Milada C, Wyller Vegard B, Sulheim Dag, Fagermoen Even, Winger Anette, Pedersen Edvard, Hrubos-Strøm Harald
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Pediatrics, Akershus University Hospital, Lorenskog, Norway.
J Sleep Res. 2017 Oct;26(5):595-601. doi: 10.1111/jsr.12547. Epub 2017 May 4.
Chronic fatigue syndrome (CFS) is characterized by long-lasting, disabling and unexplained fatigue that is often accompanied by unrefreshing sleep. The aim of this cross-sectional study was to investigate sleep-wake rhythm and perceived sleep in adolescent CFS patients compared to healthy individuals. We analysed baseline data on 120 adolescent CFS patients and 39 healthy individuals included in the NorCAPITAL project. Activity measures from a uniaxial accelerometer (activPAL) were used to estimate mid-sleep time (mid-point of a period with sleep) and time in bed. Scores from the Karolinska Sleep Questionnaire (KSQ) were also assessed. The activity measures showed that the CFS patients stayed significantly longer in bed, had a significantly delayed mid-sleep time and a more varied sleep-wake rhythm during weekdays compared with healthy individuals. On the KSQ, the CFS patients reported significantly more insomnia symptoms, sleepiness, awakening problems and a longer sleep onset latency than healthy individuals. These results might indicate that disrupted sleep-wake phase could contribute to adolescent CFS; however, further investigations are warranted.
慢性疲劳综合征（CFS）的特征是长期存在、使人衰弱且原因不明的疲劳，常伴有睡眠后仍感疲倦。这项横断面研究的目的是调查与健康个体相比，青少年CFS患者的睡眠-觉醒节律和主观睡眠情况。我们分析了纳入NorCAPITAL项目的120名青少年CFS患者和39名健康个体的基线数据。使用单轴加速度计（activPAL）的活动测量数据来估计睡眠时间中点（睡眠时段的中点）和卧床时间。还评估了卡罗林斯卡睡眠问卷（KSQ）的得分。活动测量结果显示，与健康个体相比，CFS患者在工作日卧床时间显著更长，睡眠时间中点显著延迟，睡眠-觉醒节律变化更大。在KSQ上，CFS患者报告的失眠症状、嗜睡、觉醒问题和入睡潜伏期比健康个体显著更多。这些结果可能表明，睡眠-觉醒阶段紊乱可能导致青少年CFS；然而，仍需进一步研究。
