Ito Y, Terao H, Noguchi T, Naito H
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan.
Poult Sci. 1988 Sep;67(9):1290-4. doi: 10.3382/ps.0671290.
Gizzerosine, which was originally found in fish meal, is a compound that causes gizzard erosion and ulceration in chicks. The action of gizzerosine on the isolated cells of chicken proventriculus was studied in the present investigations. Gizzerosine increased intracellular cyclic adenosine-3',5'-monophosphate (cAMP) levels, reaching a plateau within 30 min. Similar maxima of cAMP level were observed in the presence of histamine or gizzerosine. However, the potency of gizzerosine was approximately 1,000-fold higher than that of histamine. The action of gizzerosine was depressed by cimetidine, a histamine H2-receptor antagonist, but not by pyrilamine, a histamine H1-receptor antagonist, indicating that gizzerosine is a very strong histamine H2-receptor agonist. The mucosal cells isolated from the proventriculus by the present procedure had both histamine H1 and H2-receptors. Gizzerosine showed a higher affinity to the cell surface histamine receptor than histamine. These results partly explain the potent activity of gizzerosine in inducing gastric acid secretion and causing gizzard erosion and ulceration in chickens.
肌胃糜烂素最初是在鱼粉中发现的一种化合物，可导致雏鸡肌胃糜烂和溃疡。本研究对肌胃糜烂素对鸡腺胃分离细胞的作用进行了研究。肌胃糜烂素可提高细胞内环磷酸腺苷（cAMP）水平，30分钟内达到平台期。在组胺或肌胃糜烂素存在的情况下，观察到cAMP水平的类似最大值。然而，肌胃糜烂素的效力比组胺高约1000倍。肌胃糜烂素的作用被组胺H2受体拮抗剂西咪替丁抑制，但不被组胺H1受体拮抗剂吡苄明抑制，这表明肌胃糜烂素是一种非常强的组胺H2受体激动剂。通过本方法从腺胃分离的黏膜细胞同时具有组胺H1和H2受体。肌胃糜烂素对细胞表面组胺受体的亲和力高于组胺。这些结果部分解释了肌胃糜烂素在诱导鸡胃酸分泌以及导致肌胃糜烂和溃疡方面的强大活性。
