Ito Y, Noguchi T, Naito H
Anal Biochem. 1985 Nov 15;151(1):28-31. doi: 10.1016/0003-2697(85)90048-x.
Gizzerosine (2-amino-9-(4-imidazolyl)-7-azanonanoic acid) was discovered in fish meal as a causative material of gizzard erosion in chicks. This compound stimulates gastric acid secretion as a histamine H2-receptor agonist and induces gizzard erosion in chicks. A method of fluorometric determination of this compound was developed employing high-performance liquid chromatography. By this method, 0.2 to 5.0 micrograms of gizzerosine in fish meals was quantitated with the recovery of 95-102%. Fish meals, which induced severe gizzard erosion in chicks, contained more than 20 mg/kg of gizzerosine. The present method will be useful in preventing gizzard erosion in chicks, which is a big problem in the poultry industry all over the world.
肌胃糜烂素（2-氨基-9-（4-咪唑基）-7-氮杂壬酸）是在鱼粉中发现的，它是雏鸡肌胃糜烂的致病物质。该化合物作为组胺H2受体激动剂刺激胃酸分泌，并在雏鸡中诱发肌胃糜烂。开发了一种采用高效液相色谱法荧光测定该化合物的方法。通过该方法，可对鱼粉中0.2至5.0微克的肌胃糜烂素进行定量，回收率为95%-102%。在雏鸡中诱发严重肌胃糜烂的鱼粉，其肌胃糜烂素含量超过20毫克/千克。本方法将有助于预防雏鸡的肌胃糜烂，这是全球家禽业中的一个大问题。
