Ionis Pharmaceuticals, Inc , 2855 Gazelle Court, Carlsbad, California 92010, United States.
Pfizer Inc. , One Burtt Road, Andover, Massachusetts 01810, United States.
J Chem Inf Model. 2017 Jun 26;57(6):1233-1239. doi: 10.1021/acs.jcim.6b00442. Epub 2017 May 19.
Hierarchical Editing Language for Macromolecules (HELM version 2.0) is a molecular line notation similar to SMILEs but specifically for communicating and managing biopolymer structures. The HELM project, part of the Pistoia Alliance nonprofit organization, has been tasked to develop and promote HELM as a global exchange format and recently released version 2.0 of the specification. Here we will describe the specifics of the HELM v2.0 notation along with the large ecosystem of software to support HELM-based structure management. We will highlight a recent open-source software and database for HELM monomers and a new, simpler approach to deploying a large complicated molecular management system.
大分子层次编辑语言 (HELM 版本 2.0) 是一种类似于 SMILES 的分子行标记法，但专门用于交流和管理生物聚合物结构。HELM 项目是 Pistoia 联盟非营利组织的一部分，其任务是开发和推广 HELM 作为一种全球交换格式，并于最近发布了规范的 2.0 版本。在这里，我们将描述 HELM v2.0 符号的具体细节，以及支持基于 HELM 的结构管理的大型软件生态系统。我们将重点介绍最近的 HELM 单体的开源软件和数据库，以及一种新的、更简单的方法来部署大型复杂分子管理系统。
