Boccara Franck
Division of Cardiology, Saint Antoine University Hospital, APHP, INSERM, UMR-S 938, UPMC, Paris, France.
AIDS. 2017 Jun 1;31 Suppl 2:S157-S163. doi: 10.1097/QAD.0000000000001384.
: Populations living with HIV who access effective antiretroviral therapies are ageing and thus facing chronic disease-related comorbidities. Cardiovascular disease is now a leading cause of morbidity and mortality in the HIV population as in the general population. The increased incidence of cardiovascular complications experienced by the HIV population is due to physiological aging and consequently the increased risk of hypertension, diabetes, and renal failure. Whether HIV itself is an additive and independent risk factor for cardiovascular disease (CVD) remains a central question. If and how HIV impacts the ageing process is an important and related question. The purpose of the present review is to highlight the risk of CVD in the ageing HIV population, particularly concerning atherosclerotic CVD (ASCVD) and heart failure, and to address effective CVD prevention in an aging HIV population at risk of poly-pharmacy.
接受有效抗逆转录病毒疗法的艾滋病毒感染者正在老龄化,因此面临与慢性病相关的合并症。与普通人群一样,心血管疾病现在是艾滋病毒感染者发病和死亡的主要原因。艾滋病毒感染者心血管并发症发病率增加是由于生理衰老,进而导致患高血压、糖尿病和肾衰竭的风险增加。艾滋病毒本身是否是心血管疾病(CVD)的一个附加且独立的风险因素仍然是一个核心问题。艾滋病毒是否以及如何影响衰老过程是一个重要的相关问题。本综述的目的是强调老年艾滋病毒感染者患心血管疾病的风险,特别是关于动脉粥样硬化性心血管疾病(ASCVD)和心力衰竭,并探讨在有多重用药风险的老年艾滋病毒感染者中有效的心血管疾病预防措施。