Micali Cristina, Russotto Ylenia, Facciolà Alessio, Marino Andrea, Celesia Benedetto Maurizio, Pistarà Eugenia, Caci Grazia, Nunnari Giuseppe, Pellicanò Giovanni Francesco, Venanzi Rullo Emmanuele
Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98100 Messina, Italy.
Infect Dis Rep. 2022 Mar 25;14(2):228-242. doi: 10.3390/idr14020028.
Kaposi sarcoma (KS) is a multifocal lympho-angioproliferative, mesenchymal low-grade tumor associated with a γ2-herpesvirus, named Kaposi sarcoma-associated virus or human herpesvirus (KSHV/HHV8). The lung is considered a usual anatomical location of KS, despite being infrequent, often in association with extensive mucocutaneous lesions and very uncommonly as an isolated event. We report a case of a pulmonary KS (pKS) in a human immunodeficiency virus (HIV) naïve patient, which was atypical due to a lack of cutaneous involvement and an absence of respiratory symptoms. The pKS was initially identified as a tumoral suspected nodular lesion and only after immunohistochemical analysis was it characterized as KS. Furthermore, the diagnosis of pKS led to the discovery of the HIV-seropositive status of the patient, previously unknown. Our report underlines the importance of considering pKS even without skin lesions and as a first manifestation of HIV infection. We also reviewed literature on the current knowledge about pKS in people living with HIV (PLWH) to underline how one of the most common HIV/acquired immunodeficiency syndrome (AIDS) associated tumors can have a challenging localization and be difficult to recognize.
卡波西肉瘤（KS）是一种多灶性淋巴血管增生性间质性低度肿瘤，与一种γ2疱疹病毒有关，该病毒名为卡波西肉瘤相关病毒或人类疱疹病毒（KSHV/HHV8）。尽管肺部是KS的常见解剖部位，但并不常见，通常与广泛的皮肤黏膜病变相关，极少单独出现。我们报告一例在未感染人类免疫缺陷病毒（HIV）的患者中发生的肺部KS（pKS）病例，该病例不典型，因为没有皮肤受累且无呼吸道症状。pKS最初被识别为疑似肿瘤性结节病变，仅在免疫组织化学分析后才被确诊为KS。此外，pKS的诊断导致发现该患者此前未知的HIV血清阳性状态。我们的报告强调，即使没有皮肤病变，也应考虑pKS作为HIV感染的首发表现。我们还回顾了关于HIV感染者（PLWH）中pKS的现有知识的文献，以强调这种最常见的HIV/获得性免疫缺陷综合征（AIDS）相关肿瘤之一如何具有具有挑战性的定位且难以识别。
