周围神经萎缩加上较高的脑脊液颗粒蛋白预示着肌萎缩侧索硬化症中的轴突损伤。
Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis.
机构信息
Department of Neurology, Otto-von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.
German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association, Magdeburg, Germany.
出版信息
Muscle Nerve. 2018 Feb;57(2):273-278. doi: 10.1002/mus.25682. Epub 2017 May 22.
INTRODUCTION
We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS).
METHODS
We included 55 ALS patients who had forearm median and ulnar nerve CSA, cerebrospinal fluid (CSF) PGRN, and serum PGRN measures available. CSF PGRN was normalized against the CSF / serum albumin ratio (Q ). Using age, sex, height, and weight adjusted general linear models, we examined CSA × CSF PGRN interaction effects on various measures.
RESULTS
There was a medium-effect size inverse relationship between CSA and CSF PGRN, but not between CSA and serum PGRN. Lower CSA values together with higher CSF PGRN levels were linked to smaller motor amplitudes.
DISCUSSION
In ALS, the constellation of peripheral nerve atrophy together with higher CSF PGRN levels indicates pronounced axonal damage. Muscle Nerve 57: 273-278, 2018.
简介
我们旨在研究超声外周横截面积（CSA）和颗粒体蛋白前体（PGRN）是否相互关联，以及它们是否相互作用以预测肌萎缩侧索硬化症（ALS）的临床和临床相关指标。
方法
我们纳入了 55 名 ALS 患者，他们有前臂正中神经和尺神经 CSA、脑脊液（CSF）PGRN 和血清 PGRN 测量值。CSF PGRN 通过 CSF/血清白蛋白比值（Q）进行标准化。使用年龄、性别、身高和体重调整的一般线性模型，我们检查了 CSA×CSF PGRN 对各种指标的相互作用效应。
结果
CSA 与 CSF PGRN 之间存在中等效应大小的反比关系，但 CSA 与血清 PGRN 之间不存在这种关系。较低的 CSA 值与较高的 CSF PGRN 水平相关，表明运动幅度较小。
讨论
在 ALS 中，周围神经萎缩与较高的 CSF PGRN 水平一起表明明显的轴突损伤。肌肉神经 57：273-278，2018。
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