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糖尿病相关并发症及血糖控制方面的年龄差异。

Age differences in diabetes-related complications and glycemic control.

作者信息

Shamshirgaran S M, Mamaghanian A, Aliasgarzadeh A, Aiminisani N, Iranparvar-Alamdari M, Ataie J

机构信息

Department of Statistics and Epidemiology, School of Health Sciences Tabriz University of Medical Sciences, Tabriz, Iran.

Injury Epidemiology Prevention Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

BMC Endocr Disord. 2017 May 4;17(1):25. doi: 10.1186/s12902-017-0175-5.

Abstract

BACKGROUND

This study aimed to examine the associations of age with the presence of complications and glycemic control in the Northwest of Iran.

METHODS

A total of 649 people with diabetes who were >25 years old and had a caring record in diabetes clinics in two Northwestern provinces of Iran during 2014-15, were recruited in this cross-sectional study. General information including demographic, socioeconomic status and lifestyle factors were collected by trained interviewers. Clinical information was retrieved from clinic's record. Univariate and multivariate logistic regression were performed to assess the predictors of diabetes outcome of interest as well as to clarify the role of age in relation to these outcomes.

RESULTS

Compared to the age group of ≤49, the middle age group (50-59) and the older age group (60 years of age and older) were less likely to report poor glycemic control (OR fully adjusted = 0.49 95% CI: 0.28-0.86 and (OR = 0.44 95% CI: 0.24-0.80), respectively. Additionally, poor glycemic control was associated with income level, disease duration, hypercholesterolemia, high level of LDL and hypertension. In contrast, age was associated with the highest percentage of complications. People with duration of >7 years of disease record were 6 times more likely to have complications (OR = 5.98 95% CI: 2.35-15.22).

CONCLUSION

Although the prevalence of complications was higher among the older diabetic patients, they had a better glycemic control. The influential factors were variably associated with the two diabetes-related outcomes; therefore, a more comprehensive risk profiles assessment is needed for glycemic control.

摘要

背景

本研究旨在探讨伊朗西北部地区年龄与并发症发生情况及血糖控制之间的关联。

方法

本横断面研究纳入了2014 - 2015年期间伊朗西北部两个省份糖尿病诊所中年龄大于25岁且有护理记录的649例糖尿病患者。由经过培训的访谈员收集包括人口统计学、社会经济状况和生活方式因素在内的一般信息。临床信息从诊所记录中获取。进行单因素和多因素逻辑回归分析,以评估感兴趣的糖尿病结局的预测因素,并阐明年龄与这些结局的关系。

结果

与年龄≤49岁组相比,中年组(50 - 59岁)和老年组(60岁及以上)报告血糖控制不佳的可能性较小(完全调整后的OR分别为0.49,95%CI:0.28 - 0.86和OR = 0.44,95%CI:0.24 - 0.80)。此外,血糖控制不佳与收入水平、病程、高胆固醇血症、低密度脂蛋白水平升高和高血压有关。相比之下,年龄与并发症的发生率最高相关。病程记录超过7年的患者发生并发症的可能性高6倍(OR = 5.98,95%CI:2.35 - 15.22)。

结论

尽管老年糖尿病患者并发症的患病率较高,但他们的血糖控制较好。影响因素与两种糖尿病相关结局的关联各不相同;因此,需要对血糖控制进行更全面的风险评估。

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