Fenelon M, Quinque E, Arrive E, Catros S, Fricain J C
Department of Dentistry, University of Bordeaux, Bordeaux, France; University of Bordeaux, 16 à 20, cours de la Marne 33082 Bordeaux France.
Department of Dentistry, University of Bordeaux, Bordeaux, France.
Int J Oral Maxillofac Surg. 2017 Nov;46(11):1505-1511. doi: 10.1016/j.ijom.2017.03.032. Epub 2017 May 2.
This retrospective study aimed to evaluate the efficacy of clonazepam and amitriptyline in the treatment of burning mouth syndrome (BMS). A single-centre retrospective cohort study was performed among patients diagnosed with BMS. Either clonazepam or amitriptyline was administered. Patients were asked to evaluate their pain using a 10-point verbal numerical scale (VNS) at baseline, and at 6 weeks and 3 months of treatment. Mean pain-relief values were assessed according to the treatment received using the Kruskal-Wallis test. Thirty-nine patients (85% female) were included. The mean age was 65±10.5years. The mean VNS score at baseline was 7.1±2.0 in patients treated with clonazepam and 7.5±1.1 in those treated with amitriptyline. The mean VNS scores in the clonazepam and amitriptyline groups were 4.9±2.4 and 6.1±2.6, respectively, after 6 weeks of treatment (P=0.498) and 4.4±2.0 and 4.1±2.7, respectively, after 3 months (P=0.509). There was no difference between the two treatments in terms of pain reduction. Clonazepam as well as amitriptyline may be an effective treatment for BMS.
这项回顾性研究旨在评估氯硝西泮和阿米替林治疗灼口综合征（BMS）的疗效。在诊断为BMS的患者中进行了一项单中心回顾性队列研究。给予氯硝西泮或阿米替林治疗。要求患者在基线时以及治疗6周和3个月时使用10分言语数字评分量表（VNS）评估疼痛程度。根据接受的治疗，使用Kruskal-Wallis检验评估平均疼痛缓解值。共纳入39例患者（85%为女性）。平均年龄为65±10.5岁。接受氯硝西泮治疗的患者基线时VNS平均评分为7.1±2.0，接受阿米替林治疗的患者为7.5±1.1。治疗6周后，氯硝西泮组和阿米替林组的VNS平均评分分别为4.9±2.4和6.1±2.6（P=0.498），3个月后分别为4.4±2.0和4.1±2.7（P=0.509）。两种治疗在减轻疼痛方面没有差异。氯硝西泮和阿米替林可能都是治疗BMS的有效方法。
