Ridder B, Mattes D S, Nesterov-Mueller A, Breitling F, Meier M A R
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Chem Commun (Camb). 2017 May 17;53(40):5553-5556. doi: 10.1039/c7cc01945a.
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated.
研究了乌吉四组分反应，作为通过合成后侧链修饰使肽阵列功能化的工具，以模拟翻译后过程。此外，作为阵列上合成拟肽的概念验证，还展示了将乌吉单元整合到正在生长的肽链中的过程。
