Velasco M E, Roessmann U, Gambetti P
J Neuropathol Exp Neurol. 1982 Mar;41(2):150-63. doi: 10.1097/00005072-198203000-00005.
The presence of glial fibrillary acidic protein (GFAP) was studied in human pituitary glands with the peroxidase-antiperoxidase (PAP) method. Positive reaction was observed in cells and processes of the neurohypophysis, in occasional cells lining the Rathke's cysts of the pars intermedia, and in scattered star-shaped cells and small follicles of the pars distalis. GFAP immunoreactivity was sparse and variable in amount from case to case. An increase in GFAP-immunoreactivity was observed as a reaction to injury. GFAP-positive cells were seen within and around pituitary adenomas regardless of their secretory cell type. Evidence is presented to indicate that these cells do not contain conventional pituitary hormones. It is postulated that the GFAP-positive cells of the pars distalis are nonsecretory elements, identical to the folliculostellate cells. They may become visible by immunostaining following increased synthesis of GFAP. The latter may be a response to cell injury or metabolic changes in adjacent secretory elements. A similar reaction in pituicytes may explain the appearance of immunoreactive GFAP in the neural lobe. The presence of GFAP in the adenohypophysis suggests that some of their cells are neuroectodermal in origin.
采用过氧化物酶-抗过氧化物酶（PAP）法研究了人垂体中胶质纤维酸性蛋白（GFAP）的存在情况。在神经垂体的细胞和突起中、中间部Rathke囊肿内衬的偶尔细胞中以及远侧部散在的星形细胞和小滤泡中观察到阳性反应。GFAP免疫反应性稀疏，且不同病例间数量存在差异。观察到GFAP免疫反应性增加是对损伤的一种反应。无论垂体腺瘤的分泌细胞类型如何，在腺瘤内部及周围均可见GFAP阳性细胞。有证据表明这些细胞不含有传统的垂体激素。据推测，远侧部的GFAP阳性细胞是非分泌性成分，与滤泡星形细胞相同。在GFAP合成增加后，它们可能通过免疫染色显现出来。后者可能是对细胞损伤或相邻分泌成分代谢变化的一种反应。垂体细胞中的类似反应可能解释了神经叶中免疫反应性GFAP的出现。腺垂体中GFAP的存在表明其一些细胞起源于神经外胚层。
