Xie X, Shi X, Liu M
Department of Geriatrics, Peking University First Hospital, Beijing, China.
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Scand J Immunol. 2017 Jul;86(1):50-58. doi: 10.1111/sji.12560.
Recently, the roles of toll like receptor (TLR) gene polymorphisms in atherosclerotic diseases were extensively investigated, with conflicting results. Therefore, we performed this study to better assess the relationship between TLR gene variants and atherosclerosis. Eligible studies were searched in PubMed, MEDLINE, EMBASE, Web of Science and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate associations between TLR gene polymorphisms and atherosclerosis. A total of 40 studies covering 19,657 cases and 15,660 controls were finally included in our systematic review and meta-analysis. Significant correlations with atherosclerosis susceptibility were found for the TLR1 rs5743551 polymorphism (dominant model: 95% CI 1.03-1.79; recessive model: 95% CI 0.28-0.97; allele model: 95% CI 1.07-1.69), TLR1 rs5743611 polymorphism (dominant model: 95% CI 0.56-0.98) and TLR6 rs5743810 polymorphism (recessive model: 95% CI 0.56-0.92) in overall analyses. Moreover, further subgroup analyses revealed that TLR4 rs1927911 polymorphism was significantly associated with the risk of cerebral infarction in the recessive model (95% CI 0.46-0.96), whereas TLR4 rs4986791 polymorphism was significantly correlated with susceptibility to atherosclerosis among Asians in the dominant (95% CI 1.58-6.66), additive (95% CI 0.13-0.69) and allele (95% CI 1.58-5.53) models. However, no positive results were found for the other 13 TLR polymorphisms. In conclusion, our findings indicate that most TLR gene polymorphisms may not be implicated in the pathogenesis of atherosclerosis, whereas certain TLR gene variations, such as rs5743551, rs5743611, rs5743810, rs4986791 and rs1927911, may serve as genetic biomarkers of atherosclerotic diseases.
最近，Toll样受体（TLR）基因多态性在动脉粥样硬化疾病中的作用得到了广泛研究，但结果相互矛盾。因此，我们开展了这项研究，以更好地评估TLR基因变异与动脉粥样硬化之间的关系。在PubMed、MEDLINE、EMBASE、科学网和中国知网中检索符合条件的研究。采用比值比（OR）及95%置信区间（CI）来估计TLR基因多态性与动脉粥样硬化之间的关联。我们的系统评价和荟萃分析最终纳入了40项研究，涵盖19657例病例和15660例对照。在总体分析中，发现TLR1 rs5743551多态性（显性模型：95%CI 1.03 - 1.79；隐性模型：95%CI 0.28 - 0.97；等位基因模型：95%CI 1.07 - 1.69）、TLR1 rs5743611多态性（显性模型：95%CI 0.56 - 0.98）和TLR6 rs5743810多态性（隐性模型：95%CI 0.56 - 0.92）与动脉粥样硬化易感性存在显著相关性。此外，进一步的亚组分析显示，TLR4 rs1927911多态性在隐性模型中与脑梗死风险显著相关（95%CI 0.46 - 0.96），而TLR4 rs4986791多态性在显性（95%CI 1.58 - 6.66）、加性（95%CI 0.13 - 0.69）和等位基因（95%CI 1.58 - 5.53）模型中与亚洲人动脉粥样硬化易感性显著相关。然而，其他13种TLR多态性未发现阳性结果。总之，我们的研究结果表明，大多数TLR基因多态性可能与动脉粥样硬化的发病机制无关，而某些TLR基因变异，如rs5743551、rs5743611、rs5743810、rs4986791和rs1927911，可能作为动脉粥样硬化疾病的遗传生物标志物。
