Department of Healthcare, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Cardiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Clin Cardiol. 2019 Oct;42(10):860-865. doi: 10.1002/clc.23233. Epub 2019 Jul 24.
Some previous studies explored associations between vascular endothelial growth factor receptor 2 (VEGFR2) polymorphisms and atherosclerotic cardiovascular diseases (ASCVD), with conflicting findings.
We thought that VEGFR2 polymorphisms may influence susceptibility to ASCVD. Here, we aimed to better analyze the relationship between VEGFR2 polymorphisms and ASCVD in a larger combined population by performing a meta-analysis.
We searched Pubmed, Embase, and Web of Science for related articles. We calculated odds ratio (OR) and 95% confidence interval (CI) to estimate whether there are genetic associations between VEGFR2 polymorphisms and ASCVD.
Ten studies were included for this meta-analysis (5474 cases and 8584 controls). VEGFR2 rs1870377 (dominant comparison: 0.81 (0.73-0.89), I = 56%; recessive comparison: 1.40 (1.25-1.57), I = 34%; allele comparison: 0.81 (0.76-0.87), I = 0%), rs2071559 (dominant comparison: 0.83 (0.76-0.91), I = 0%; recessive comparison: 1.22 (1.07-1.38), I = 0%; allele comparison: 0.86 (0.81-0.92), I = 0%) and rs2305948 (dominant comparison: 0.79 (0.72-0.87), I = 25%; recessive comparison: 1.44 (1.08-1.92), I = 60%; allele comparison: 0.79 (0.68-0.92), I = 73%) polymorphisms were all found to be significantly associated with susceptibility to ASCVD in general population. Subgroup analyses by type of disease revealed similar significant findings for rs1870377, rs2071559, and rs2305948 polymorphisms in coronary artery disease (CAD) subgroup. Besides, positive results were also found for rs1870377 polymorphism in ischemic stroke (IS) subgroup.
In summary, this meta-analysis proved that these VEGFR2 polymorphisms could be used to identify individual with elevated susceptibility to ASCVD.
一些先前的研究探讨了血管内皮生长因子受体 2（VEGFR2）多态性与动脉粥样硬化性心血管疾病（ASCVD）之间的关联，但其结果存在争议。
我们认为 VEGFR2 多态性可能会影响 ASCVD 的易感性。在这里，我们通过进行荟萃分析，旨在在更大的联合人群中更好地分析 VEGFR2 多态性与 ASCVD 之间的关系。
我们在 Pubmed、Embase 和 Web of Science 上搜索相关文章。我们计算了比值比（OR）和 95%置信区间（CI），以评估 VEGFR2 多态性与 ASCVD 之间是否存在遗传关联。
这项荟萃分析纳入了 10 项研究（5474 例病例和 8584 例对照）。VEGFR2 rs1870377（显性比较：0.81（0.73-0.89），I = 56%；隐性比较：1.40（1.25-1.57），I = 34%；等位基因比较：0.81（0.76-0.87），I = 0%）、rs2071559（显性比较：0.83（0.76-0.91），I = 0%；隐性比较：1.22（1.07-1.38），I = 0%；等位基因比较：0.86（0.81-0.92），I = 0%）和 rs2305948（显性比较：0.79（0.72-0.87），I = 25%；隐性比较：1.44（1.08-1.92），I = 60%；等位基因比较：0.79（0.68-0.92），I = 73%）多态性均与一般人群 ASCVD 的易感性显著相关。按疾病类型进行亚组分析，rs1870377、rs2071559 和 rs2305948 多态性在冠状动脉疾病（CAD）亚组中也得到了类似的显著发现。此外，rs1870377 多态性在缺血性卒中（IS）亚组中也得到了阳性结果。
综上所述，这项荟萃分析证明，这些 VEGFR2 多态性可用于识别 ASCVD 易感性增加的个体。
