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造血干细胞移植受者和血液系统恶性肿瘤患者感染登革病毒后的病毒血症持续时间延长。

Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies.

作者信息

de Souza Pereira Bárbara Brito, Darrigo Junior Luiz Guilherme, de Mello Costa Thalita Cristina, Felix Alvina Clara, Simoes Belinda P, Stracieri Ana Beatriz, da Silva Paula Moreira, Mauad Marcos, Machado Clarisse M

机构信息

Virology Laboratory, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.

Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.

出版信息

Transpl Infect Dis. 2017 Aug;19(4). doi: 10.1111/tid.12721. Epub 2017 Jun 26.

Abstract

Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown. In the present series, we describe five cases of dengue in patients living in endemic areas, emphasizing the prolonged course of the disease and the occurrence of prolonged viremia.

摘要

发热、皮疹、头痛和血小板减少被认为是登革热感染的特征。然而,这些症状在造血干细胞移植受者和血液肿瘤患者的感染性和非感染性并发症中经常出现。因此,登革热的实验室确诊对于在流行地区和非流行地区及时干预和妥善管理登革热至关重要。由于尚未在这些人群中开展关于登革热的前瞻性研究,登革热的实际发病率和死亡率尚不清楚。在本系列病例中,我们描述了居住在流行地区的5例登革热患者,强调了疾病病程延长和病毒血症持续时间延长的情况。

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