• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肿瘤切除及根治性放疗后具有局部复发高风险的浸润性乳腺癌的病理特征。

Pathological features of invasive breast cancer associated with a high risk of local recurrence after tumour excision and radical radiotherapy.

作者信息

Bulman A S, Lindley R P, Parsons P, Ellis H

机构信息

Westminster Hospital, London.

出版信息

Ann R Coll Surg Engl. 1988 Sep;70(5):289-92.

PMID:2847625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2498825/
Abstract

The histological slides of 273 breast cancer patients, treated by local excision and radiotherapy and followed up for 2-6 years, were reviewed in search of factors predictive of local recurrence. Local recurrence was found to be most closely related to the combination of a high proportion of intraduct carcinoma and extensive necrosis (comedocarcinoma). This latter group of 18 patients had a local recurrence rate of 50%. These patients are of particular interest since they form a small group with readily identifiable histological features.

摘要

对273例接受局部切除和放疗并随访2至6年的乳腺癌患者的组织学切片进行了复查，以寻找预测局部复发的因素。发现局部复发与导管内癌比例高和广泛坏死（粉刺癌）的组合最为密切相关。后一组18例患者的局部复发率为50%。这些患者特别值得关注，因为他们构成了一个具有易于识别的组织学特征的小群体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/2498825/e4a0ab7e57e4/annrcse01552-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/2498825/e4a0ab7e57e4/annrcse01552-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e99/2498825/e4a0ab7e57e4/annrcse01552-0034-a.jpg

相似文献

1
Pathological features of invasive breast cancer associated with a high risk of local recurrence after tumour excision and radical radiotherapy.肿瘤切除及根治性放疗后具有局部复发高风险的浸润性乳腺癌的病理特征。
Ann R Coll Surg Engl. 1988 Sep;70(5):289-92.
2
Clinical outcome after selective treatment of patients diagnosed with ductal carcinoma in situ of the breast.对诊断为乳腺导管原位癌的患者进行选择性治疗后的临床结果。
Ann Surg Oncol. 2008 Jan;15(1):235-43. doi: 10.1245/s10434-007-9659-2. Epub 2007 Nov 7.
3
Does intraductal breast cancer spread in a segmental distribution? An analysis of residual tumour burden following segmental mastectomy using tumour bed biopsies.导管内乳腺癌是否呈节段性扩散？一项使用瘤床活检对节段性乳房切除术后残余肿瘤负荷的分析。
Eur J Surg Oncol. 2001 Feb;27(1):21-5. doi: 10.1053/ejso.2000.1051.
4
[Local relapse in young (< or = 40 years) women with breast cancer after mastectomy or breast conserving surgery: 15-year results].[40岁及以下年轻女性乳腺癌乳房切除或保乳手术后的局部复发：15年结果]
Magy Onkol. 2005;49(3):203, 205-8. Epub 2005 Oct 25.
5
Mammographically detected, clinically occult ductal carcinoma in situ treated with breast-conserving surgery and definitive breast irradiation.经乳房钼靶检查发现、临床隐匿的导管原位癌，采用保乳手术及根治性乳房放疗进行治疗。
Cancer J Sci Am. 1996 May-Jun;2(3):158-65.
6
Audit of local recurrence rates following 'ultra'-conservative surgery for invasive breast cancer--a boost to the breast?浸润性乳腺癌“超”保守手术后局部复发率的审计——对乳房的一次推动？
Breast. 2005 Jun;14(3):224-9. doi: 10.1016/j.breast.2005.01.006. Epub 2005 Apr 18.
7
Local recurrence rates in breast cancer patients treated with intraoperative electron-boost radiotherapy versus postoperative external-beam electron-boost irradiation. A sequential intervention study.接受术中电子束增强放疗与术后外照射电子束增强放疗的乳腺癌患者的局部复发率。一项序贯干预研究。
Strahlenther Onkol. 2004 Jan;180(1):38-44. doi: 10.1007/s00066-004-1190-9.
8
Defining negative margins in DCIS patients treated with breast conservation therapy: The University of Chicago experience.保乳治疗的导管原位癌患者切缘阴性的界定：芝加哥大学的经验
Breast J. 2005 Jul-Aug;11(4):242-7. doi: 10.1111/j.1075-122X.2005.21617.x.
9
Nipple-sparing mastectomy in association with intra operative radiotherapy (ELIOT): A new type of mastectomy for breast cancer treatment.保留乳头的乳房切除术联合术中放疗（ELIOT）：一种用于乳腺癌治疗的新型乳房切除术。
Breast Cancer Res Treat. 2006 Mar;96(1):47-51. doi: 10.1007/s10549-005-9033-7. Epub 2005 Oct 27.
10
Local recurrence after conservative surgery and radiation therapy for ductal carcinoma in situ: Possible importance of family history.导管原位癌保守手术及放疗后的局部复发：家族史的潜在重要性
Cancer J Sci Am. 1995 May-Jun;1(1):55-61.

引用本文的文献

1
Pathological outcomes of transanal versus laparoscopic total mesorectal excision for rectal cancer: a systematic review with meta-analysis.经肛门与腹腔镜全直肠系膜切除术治疗直肠癌的病理结局：系统评价与荟萃分析。
Surg Endosc. 2018 Jun;32(6):2632-2642. doi: 10.1007/s00464-018-6103-6. Epub 2018 Feb 20.
2
Standardized and reproducible methodology for the comprehensive and systematic assessment of surgical resection margins during breast-conserving surgery for invasive breast cancer.用于浸润性乳腺癌保乳手术中手术切缘综合系统评估的标准化且可重复的方法。
BMC Cancer. 2009 Jul 27;9:254. doi: 10.1186/1471-2407-9-254.
3

本文引用的文献

1
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.乳腺癌的组织学分级与预后；对1409例病例的研究，其中359例已随访15年。
Br J Cancer. 1957 Sep;11(3):359-77. doi: 10.1038/bjc.1957.43.
2
Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast.比较乳腺癌小肿瘤患者行根治性乳房切除术与象限切除术、腋窝淋巴结清扫术及放射治疗的效果。
N Engl J Med. 1981 Jul 2;305(1):6-11. doi: 10.1056/NEJM198107023050102.
3
Conservative excision and radiotherapy for early breast cancer--an acceptable alternative?
Histopathological study of local residual carcinoma after simulated lumpectomy.
模拟乳房肿瘤切除术局部残留癌的组织病理学研究
Surg Today. 1995;25(4):329-33. doi: 10.1007/BF00311255.
4
The primary management of breast cancer: is breast conservation feasible for all patients?乳腺癌的主要治疗方法：对所有患者而言保乳手术是否可行？
Ann R Coll Surg Engl. 1989 Nov;71(6):390-3.
早期乳腺癌的保守性切除与放疗——一种可接受的替代方案？
Clin Oncol. 1984 Mar;10(1):45-58.
4
Time course and prognosis of local recurrence following primary radiation therapy for early breast cancer.早期乳腺癌初次放射治疗后局部复发的时间进程及预后
J Clin Oncol. 1984 Jan;2(1):37-41. doi: 10.1200/JCO.1984.2.1.37.
5
Breast conservation in the treatment of early breast cancer. A 20-year follow-up.
Cancer. 1984 Jan 15;53(2):349-55. doi: 10.1002/1097-0142(19840115)53:2<349::aid-cncr2820530230>3.0.co;2-b.
6
Pathologic predictors of early local recurrence in Stage I and II breast cancer treated by primary radiation therapy.接受原发性放射治疗的Ⅰ期和Ⅱ期乳腺癌早期局部复发的病理预测因素。
Cancer. 1984 Mar 1;53(5):1049-57. doi: 10.1002/1097-0142(19840301)53:5<1049::aid-cncr2820530506>3.0.co;2-o.
7
Margins of "lumpectomy" for breast cancer.乳腺癌“保乳手术”的切缘
Hum Pathol. 1986 Apr;17(4):330-2. doi: 10.1016/s0046-8177(86)80455-5.
8
Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer.一项比较全乳切除术与保乳手术加或不加放疗治疗乳腺癌的随机临床试验的五年结果。
N Engl J Med. 1985 Mar 14;312(11):665-73. doi: 10.1056/NEJM198503143121101.
9
Local control and survival of breast cancer treated by limited surgery followed by irradiation.采用局部手术联合放疗治疗乳腺癌的局部控制情况及生存率。
Int J Radiat Oncol Biol Phys. 1986 Jun;12(6):873-8. doi: 10.1016/0360-3016(86)90379-2.
10
Interim results of treatment of breast cancer with breast conservation for all patients.
Surgery. 1987 Apr;101(4):395-9.