核糖核苷酸还原酶抑制对感染1型单纯疱疹病毒的阿昔洛韦处理细胞中嘧啶脱氧核苷酸代谢的影响。
Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.
作者信息
Karlsson A, Harmenberg J
机构信息
Department of Virology, National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 1988 Jul;32(7):1100-2. doi: 10.1128/AAC.32.7.1100.
Abstract
The pyrimidine metabolism of fibroblasts infected with herpes simplex virus type 1 was studied. Herpes simplex virus type 1 infection increased the dTTP pool and thymidylate synthetase activity but reduced thymidine excretion. Addition of acyclovir to infected cells increased thymidine excretion, the dTTP pool, and thymidylate synthetase activity. Addition of a virus-specific ribonucleotide reductase inhibitor (A723U) decreased all three. The synergy between the two compounds is discussed.
摘要
对感染1型单纯疱疹病毒的成纤维细胞的嘧啶代谢进行了研究。1型单纯疱疹病毒感染增加了脱氧胸苷三磷酸（dTTP）池和胸苷酸合成酶活性，但减少了胸腺嘧啶核苷排泄。向感染细胞中添加阿昔洛韦增加了胸腺嘧啶核苷排泄、dTTP池和胸苷酸合成酶活性。添加病毒特异性核糖核苷酸还原酶抑制剂（A723U）则降低了这三者。讨论了这两种化合物之间的协同作用。
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