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核糖核苷酸还原酶抑制对感染1型单纯疱疹病毒的阿昔洛韦处理细胞中嘧啶脱氧核苷酸代谢的影响。

Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.

作者信息

Karlsson A, Harmenberg J

机构信息

Department of Virology, National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.

出版信息

Antimicrob Agents Chemother. 1988 Jul;32(7):1100-2. doi: 10.1128/AAC.32.7.1100.

DOI:10.1128/AAC.32.7.1100
PMID:2847642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172354/
Abstract

The pyrimidine metabolism of fibroblasts infected with herpes simplex virus type 1 was studied. Herpes simplex virus type 1 infection increased the dTTP pool and thymidylate synthetase activity but reduced thymidine excretion. Addition of acyclovir to infected cells increased thymidine excretion, the dTTP pool, and thymidylate synthetase activity. Addition of a virus-specific ribonucleotide reductase inhibitor (A723U) decreased all three. The synergy between the two compounds is discussed.

摘要

对感染1型单纯疱疹病毒的成纤维细胞的嘧啶代谢进行了研究。1型单纯疱疹病毒感染增加了脱氧胸苷三磷酸（dTTP）池和胸苷酸合成酶活性，但减少了胸腺嘧啶核苷排泄。向感染细胞中添加阿昔洛韦增加了胸腺嘧啶核苷排泄、dTTP池和胸苷酸合成酶活性。添加病毒特异性核糖核苷酸还原酶抑制剂（A723U）则降低了这三者。讨论了这两种化合物之间的协同作用。

相似文献

1
Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.核糖核苷酸还原酶抑制对感染1型单纯疱疹病毒的阿昔洛韦处理细胞中嘧啶脱氧核苷酸代谢的影响。
Antimicrob Agents Chemother. 1988 Jul;32(7):1100-2. doi: 10.1128/AAC.32.7.1100.
2
Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.通过抑制核糖核苷酸还原酶增强阿昔洛韦的抗疱疹病毒活性。
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4254-7. doi: 10.1073/pnas.82.12.4254.
3
2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir.2-乙酰吡啶5-[(二甲氨基)硫代羰基]-硫代碳酰肼(A1110U)，一种单纯疱疹病毒和水痘-带状疱疹病毒核糖核苷酸还原酶的强效失活剂以及阿昔洛韦的增效剂。
Proc Natl Acad Sci U S A. 1989 Feb;86(3):1051-5. doi: 10.1073/pnas.86.3.1051.
4
Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.单纯疱疹病毒核糖核苷酸还原酶突变体对阿昔洛韦高度敏感。
Antimicrob Agents Chemother. 1989 Aug;33(8):1395-9. doi: 10.1128/AAC.33.8.1395.
5
Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir.单纯疱疹病毒核糖核苷酸还原酶的灭活剂：血液学特征及阿昔洛韦抗病毒活性的体内增强作用
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6
Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.病毒胸苷激酶抑制剂的证明及其对单纯疱疹病毒感染细胞中脱氧核苷酸代谢的影响。
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7
Topical treatment of infection with acyclovir-resistant mucocutaneous herpes simplex virus with the ribonucleotide reductase inhibitor 348U87 in combination with acyclovir.使用核糖核苷酸还原酶抑制剂348U87联合阿昔洛韦对耐阿昔洛韦的黏膜皮肤单纯疱疹病毒感染进行局部治疗。
Antimicrob Agents Chemother. 1993 May;37(5):975-9. doi: 10.1128/AAC.37.5.975.
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Role of viral ribonucleotide reductase in the increase of dTTP pool size in herpes simplex virus-infected Vero cells.病毒核糖核苷酸还原酶在单纯疱疹病毒感染的非洲绿猴肾细胞中增加脱氧胸苷三磷酸池大小的作用。
J Gen Virol. 1991 Jun;72 ( Pt 6):1441-4. doi: 10.1099/0022-1317-72-6-1441.
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Ribonucleotide reductase: an important enzyme in the replication of herpes simplex virus type 1 and a target for antiviral chemotherapy.核糖核苷酸还原酶：单纯疱疹病毒1型复制中的一种重要酶及抗病毒化疗的靶点。
Chemotherapy. 1995 Sep-Oct;41(5):384-95. doi: 10.1159/000239371.
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Ribonucleotide reductase induced by varicella zoster virus. Characterization, and potentiation of acyclovir by its inhibition.水痘带状疱疹病毒诱导的核糖核苷酸还原酶。特性及其对阿昔洛韦的抑制增强作用。
Biochem Pharmacol. 1987 Dec 15;36(24):4341-6. doi: 10.1016/0006-2952(87)90682-4.

引用本文的文献

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Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.甲氨蝶呤的抗巨细胞病毒活性与巨细胞病毒感染细胞对药物的优先摄取有关。
Antimicrob Agents Chemother. 1996 Feb;40(2):433-6. doi: 10.1128/AAC.40.2.433.
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2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir.2-乙酰吡啶5-[(二甲基氨基)硫代羰基]-硫代碳酰肼(1110U81)可有效抑制人巨细胞病毒复制，并增强更昔洛韦的抗病毒作用。
Antimicrob Agents Chemother. 1993 Mar;37(3):602-4. doi: 10.1128/AAC.37.3.602.
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Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit.通过与大肠杆菌肠毒素B亚基相连的抗病毒肽的受体介导进入对疱疹病毒复制的特异性抑制。
Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8994-8. doi: 10.1073/pnas.91.19.8994.
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Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.阿昔洛韦。对其抗病毒活性、药代动力学特性及治疗效果的重新评估。
Drugs. 1994 Jan;47(1):153-205. doi: 10.2165/00003495-199447010-00009.
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Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.阿昔洛韦。对其抗病毒活性、药代动力学特性及治疗效果的最新综述。
Drugs. 1989 Mar;37(3):233-309. doi: 10.2165/00003495-198937030-00002.
6
Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.单纯疱疹病毒核糖核苷酸还原酶突变体对阿昔洛韦高度敏感。
Antimicrob Agents Chemother. 1989 Aug;33(8):1395-9. doi: 10.1128/AAC.33.8.1395.
7
2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir.2-乙酰吡啶5-[(二甲氨基)硫代羰基]-硫代碳酰肼(A1110U)，一种单纯疱疹病毒和水痘-带状疱疹病毒核糖核苷酸还原酶的强效失活剂以及阿昔洛韦的增效剂。
Proc Natl Acad Sci U S A. 1989 Feb;86(3):1051-5. doi: 10.1073/pnas.86.3.1051.
8
Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir.单纯疱疹病毒核糖核苷酸还原酶的灭活剂：血液学特征及阿昔洛韦抗病毒活性的体内增强作用
Antimicrob Agents Chemother. 1992 May;36(5):934-7. doi: 10.1128/AAC.36.5.934.

本文引用的文献

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Phosphorylation of acyclovir diphosphate by cellular enzymes.阿昔洛韦二磷酸被细胞酶磷酸化。
Biochem Pharmacol. 1982 Dec 1;31(23):3879-84. doi: 10.1016/0006-2952(82)90305-7.
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Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.在细胞培养中对胸腺嘧啶核苷逆转核苷类似物抗疱疹活性的动力学分析。
Antimicrob Agents Chemother. 1983 Nov;24(5):819-22. doi: 10.1128/AAC.24.5.819.
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Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme.单纯疱疹病毒1型诱导的核糖核苷酸还原酶。一种独特酶的特性。
J Biol Chem. 1983 Aug 25;258(16):9831-8.
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Intracellular pools of thymidine reduce the antiviral action of acyclovir.
Intervirology. 1983;20(1):48-51. doi: 10.1159/000149373.
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A novel method for determining the sensitivity of herpes simplex virus to antiviral compounds.一种测定单纯疱疹病毒对抗病毒化合物敏感性的新方法。
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Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1.阿昔洛韦对感染1型单纯疱疹病毒的非洲绿猴肾细胞中脱氧核苷三磷酸池水平的影响。
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Influence of cells and virus multiplicity on the inhibition of herpesviruses with acycloguanosine.
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Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.鸟苷酸激酶对阿昔洛韦（无环鸟苷）单磷酸的磷酸化作用。
J Biol Chem. 1980 Aug 10;255(15):7204-7.
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Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.新型抗疱疹病毒化合物9-（1,3-二羟基-2-丙氧甲基）鸟嘌呤对单纯疱疹病毒感染细胞中大分子合成的影响。
Antimicrob Agents Chemother. 1984 Sep;26(3):283-8. doi: 10.1128/AAC.26.3.283.
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Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts.
J Biol Chem. 1985 May 10;260(9):5376-81.