单纯疱疹病毒核糖核苷酸还原酶突变体对阿昔洛韦高度敏感。
Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.
作者信息
Coen D M, Goldstein D J, Weller S K
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1395-9. doi: 10.1128/AAC.33.8.1395.
Abstract
Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs that potentiate acyclovir action by inhibition of viral ribonucleotide reductase.
摘要
两个在单纯疱疹病毒编码的核糖核苷酸还原酶活性方面存在缺陷的突变体，表现出对阿昔洛韦、阿非迪霉素以及在较小程度上对膦甲酸超敏的新表型。这些结果对于阿昔洛韦耐药性以及通过抑制病毒核糖核苷酸还原酶来增强阿昔洛韦作用的药物开发具有重要意义。
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Pyrophosphate analogues as inhibitors of herpes simplex virus type 1 DNA polymerase.焦磷酸盐类似物作为单纯疱疹病毒1型DNA聚合酶的抑制剂
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