Furman P A, Lambe C U, Nelson D J
Am J Med. 1982 Jul 20;73(1A):14-7. doi: 10.1016/0002-9343(82)90056-0.
The effect of acyclovir on the deoxyribonucleoside triphosphate pools of Vero cells infected with herpes simplex virus type 1 was examined. Deoxyguanosine triphosphate and deoxyadenosine triphosphate pool levels in infected cells treated with acyclovir increased dramatically compared with pool levels in untreated infected cels. The increases were due, at least in part, to inhibition of viral DNA polymerase activity which resulted in reduced utilization of the deoxyribonucleoside triphosphates. Differences of as much as 26 times were detected in the sensitivity of herpes simplex virus type 1 to inhibition by acyclovir with different Vero cell cultures. These results were due to differences in acyclovir triphosphate levels, not to differences in deoxyguanosine triphosphate levels.
研究了阿昔洛韦对感染1型单纯疱疹病毒的非洲绿猴肾细胞（Vero细胞）脱氧核糖核苷三磷酸库的影响。与未处理的感染细胞相比，用阿昔洛韦处理的感染细胞中的三磷酸脱氧鸟苷和三磷酸脱氧腺苷库水平显著增加。这种增加至少部分是由于病毒DNA聚合酶活性受到抑制，从而导致脱氧核糖核苷三磷酸的利用率降低。在不同的Vero细胞培养物中，检测到1型单纯疱疹病毒对阿昔洛韦抑制的敏感性差异高达26倍。这些结果是由于阿昔洛韦三磷酸水平的差异，而非三磷酸脱氧鸟苷水平的差异。
