术前CONUT评分对预测合并阻塞性肺病的肺腺癌患者术后无病生存期和总生存期的意义
Significance of the Preoperative CONUT Score in Predicting Postoperative Disease-free and Overall Survival in Patients with Lung Adenocarcinoma with Obstructive Lung Disease.
作者信息
Akamine Takaki, Toyokawa Gouji, Matsubara Taichi, Kozuma Yuka, Haratake Naoki, Takamori Shinkichi, Katsura Masakazu, Takada Kazuki, Shoji Fumihiro, Okamoto Tatsuro, Maehara Yoshihiko
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
出版信息
Anticancer Res. 2017 May;37(5):2735-2742. doi: 10.21873/anticanres.11625.
BACKGROUND
The usefulness of the controlling nutritional status (CONUT) score for preoperative nutritional assessment has been reported in resected colorectal and esophageal cancer, but not in lung cancer with obstructive lung disease.
PATIENTS AND METHODS
We retrospectively reviewed 109 patients with adenocarcinoma with obstructive pulmonary disease. We set 1 as the cut-off value for the CONUT score and classified patients into high (≥1) and low (0) CONUT groups.
RESULTS
Among 109 patients, 35 (32.1%) had low CONUT scores, and 74 (67.8%) had high CONUT scores. The high-CONUT group was significantly associated with a lower body mass index (p=0.025) and wild-type epidermal growth factor receptor mutation status (p=0.011). A multivariate analysis showed that the CONUT score was independently associated with disease-free and overall survival.
CONCLUSION
The results of this study suggest that the CONUT score was an independent prognostic factor for disease-free and overall survival in patients with lung adenocarcinoma with obstructive lung disease.
背景
控制营养状况（CONUT）评分在结直肠癌和食管癌切除术前营养评估中的作用已有报道，但在合并阻塞性肺疾病的肺癌中尚未见报道。
患者与方法
我们回顾性分析了109例合并阻塞性肺疾病的腺癌患者。我们将CONUT评分的临界值设定为1，并将患者分为CONUT评分高（≥1）和低（0）两组。
结果
109例患者中，35例（32.1%）CONUT评分低，74例（67.8%）CONUT评分高。CONUT评分高的组与较低的体重指数（p = 0.025）和野生型表皮生长因子受体突变状态（p = 0.011）显著相关。多因素分析显示，CONUT评分与无病生存期和总生存期独立相关。
结论
本研究结果表明，CONUT评分是合并阻塞性肺疾病的肺腺癌患者无病生存期和总生存期的独立预后因素。
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