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新型双(2,3-二氢喹唑啉-4(1H)-酮)衍生物的抗氧化、抗癌和电化学氧化还原性能。

Antioxidant, anticancer and electrochemical redox properties of new bis(2,3-dihydroquinazolin-4(1H)-one) derivatives.

机构信息

Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu, 636 011, India.

出版信息

Mol Divers. 2017 Aug;21(3):611-620. doi: 10.1007/s11030-017-9748-5. Epub 2017 May 5.

Abstract

In this paper, a series of bis(2,3-dihydroquinazolin-4(1H)-one) derivatives (4a-i, 10a-k) were synthesized by the one-pot pseudo-five-component reaction of isatoic anhydride with aromatic aldehydes and aromatic amines under reflux in glacial acetic acid. The synthesized compounds were screened for their antioxidant properties using the DPPH radical scavenging method. Compounds 4i and 10h showed potent radical scavenging activities at 20 [Formula: see text] compared to BHA and ascorbic acid. The anticancer activity of compound 4f was evaluated against human breast cancer cell line (MCF 7), and the observed [Formula: see text] was found to be 11.4 [Formula: see text]. The redox behaviour of some analogues was evaluated by cyclic voltammetric methods, and it is found that compound 7d possesses the maximum redox potential.

摘要

在本文中,通过在冰醋酸中回流的一锅法伪五组分反应,由异邻苯二甲酰亚胺与芳香醛和芳香胺合成了一系列双(2,3-二氢喹唑啉-4(1H)-酮)衍生物(4a-i,10a-k)。 采用 DPPH 自由基清除法筛选了合成化合物的抗氧化性能。 与 BHA 和抗坏血酸相比,化合物 4i 和 10h 在 20 [Formula: see text] 时表现出较强的自由基清除活性。 对化合物 4f 的抗癌活性进行了评估,其对人乳腺癌细胞系(MCF 7)的[Formula: see text]观察到为 11.4 [Formula: see text]。 通过循环伏安法评估了一些类似物的氧化还原行为,发现化合物 7d 具有最大的氧化还原电位。

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