Di Marzo V, Tippins J R, Morris H R
Department of Biochemistry, Imperial College of Science & Technology, London.
Biochem Int. 1988 Aug;17(2):235-42.
The release/biosynthesis of peptidoleukotrienes (pLT) from rat lung tissue was stimulated with either bradykinin (Bk) or the chemotactic peptide formyl-methionyl-leucinyl-phenylalanine (fMLP). Bk- and fMLP-induced stimulation of pLT levels was dose-related for leukotriene D4 (LTD4), E4 (LTE4) and total pLTs and was maximal when a 10 microM concentration of either peptide was used. This stimulation was partially counteracted by vasoactive intestinal peptide (VIP), in agreement with the previously reported VIP inhibition of platelet activating factor- and IgG-stimulated pLT biosynthesis.
用缓激肽（Bk）或趋化肽甲酰甲硫氨酰亮氨酰苯丙氨酸（fMLP）刺激大鼠肺组织中肽白三烯（pLT）的释放/生物合成。Bk和fMLP诱导的pLT水平刺激与白三烯D4（LTD4）、E4（LTE4）和总pLTs呈剂量相关，当使用10微摩尔浓度的任何一种肽时刺激最大。这种刺激被血管活性肠肽（VIP）部分抵消，这与先前报道的VIP抑制血小板活化因子和IgG刺激的pLT生物合成一致。
