环磷酸腺苷作为克氏锥虫细胞分化的诱导剂。
Cyclic AMP as an inducer of the cell differentiation of Trypanosoma cruzi.
作者信息
Rangel-Aldao R, Triana F, Fernández V, Comach G, Abate T, Montoreano R
机构信息
Centro de Investigaciones Biomédicas, Universidad de Carabobo, Venezuela.
出版信息
Biochem Int. 1988 Aug;17(2):337-44.
The addition to epimastigotes cultures of T. cruzi, of either cAMP, monobutyryl-cAMP, dibutyryl-cAMP, 8-Br-cAMP (at 2 mM each), or the cAMP-phosphodiesterase inhibitor, papaverine (0.2 mM), promoted the in vitro differentiation of these parasite forms into metacyclics. This effect of cAMP may also be exerted in vivo in the insect vector, since cAMP was detected in the urine and in the Malpighi secretion fluids of Rodnius prolixus.
向克氏锥虫的上鞭毛体培养物中添加环磷酸腺苷（cAMP）、单丁酰 - cAMP、二丁酰 - cAMP、8 - 溴 - cAMP（每种浓度均为2 mM）或环磷酸腺苷磷酸二酯酶抑制剂罂粟碱（0.2 mM），均可促进这些寄生虫形式在体外分化为循环后期锥鞭毛虫。cAMP的这种作用也可能在昆虫载体的体内发挥，因为在长红猎蝽的尿液和马尔皮基分泌液中检测到了cAMP。
Zotero 插件