2016/2017年韩国高致病性禽流感（HPAI）H5N8病毒新型基因型的遗传和系统发育特征分析
Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea.
作者信息
Kim Young-Il, Park Su-Jin, Kwon Hyeok-Il, Kim Eun-Ha, Si Young-Jae, Jeong Ju-Hwan, Lee In-Won, Nguyen Hiep Dinh, Kwon Jin-Jung, Choi Won Suk, Song Min-Suk, Kim Chul-Joong, Choi Young-Ki
机构信息
College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-763, Republic of Korea.
College of Veterinary Medicine, Chungnam National University, 220 Gung-Dong, Yuseoung-Gu, DaeJeon 305-764, Republic of Korea.
出版信息
Infect Genet Evol. 2017 Sep;53:56-67. doi: 10.1016/j.meegid.2017.05.001. Epub 2017 May 3.
During the outbreaks of highly pathogenic avian influenza (HPAI) H5N6 viruses in 2016 in South Korea, novel H5N8 viruses were also isolated from migratory birds. Phylogenetic analysis revealed that the HA gene of these H5N8 viruses belonged to clade 2.3.4.4, similarly to recent H5Nx viruses, and originated from A/Brk/Korea/Gochang1/14(H5N8), a minor lineage of H5N8 that appeared in 2014 and then disappeared. At least four reassortment events occurred with different subtypes (H5N8, H7N7, H3N8 and H10N7) and a chicken challenge study revealed that they were classified as HPAI viruses according to OIE criteria.
2016年韩国高致病性禽流感（HPAI）H5N6病毒爆发期间，还从候鸟中分离出新型H5N8病毒。系统发育分析表明，这些H5N8病毒的血凝素（HA）基因属于2.3.4.4分支，与近期的H5Nx病毒相似，起源于A/Brk/Korea/Gochang1/14(H5N8)，这是H5N8的一个次要谱系，于2014年出现后消失。这些病毒至少与不同亚型（H5N8、H7N7、H3N8和H10N7）发生了四次重配事件，一项鸡攻毒研究表明，根据世界动物卫生组织（OIE）标准，它们被归类为高致病性禽流感病毒。
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