Mannelli Giuditta, Cecconi Lorenzo, Fasolati Martina, Santoro Roberto, Franchi Alessandro, Gallo Oreste
Otorhinolaryngology-Head and Neck Surgery Unit, Department of Surgery and Translational Medicine, University of Florence, AOU-Careggi, Via Largo Palagi 1, 50134 Florence, Italy.
Department of Statistic, Computer Science, Application, University of Florence, Italy.
Am J Otolaryngol. 2017 Jul-Aug;38(4):394-400. doi: 10.1016/j.amjoto.2017.03.008. Epub 2017 Mar 31.
Adenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome.
We retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treated at our Institution. Forty-four ACC were included in this study. Multivariate analysis risk models were built to predict recurrence free probability (RFP), distant recurrence free probability (DRFP), overall survival (OS) and disease free survival (DFS).
Twenty-one patients (47.7%) died from ACC and 2.3% for other causes. The 41% presented local-regional recurrence, with a regional-RFP rate of 93%, and the 34% reported distant metastases (DM). The five and ten-year OS rates were 74% and 50%, respectively.
Recurrences were mainly influenced by the presence of perineural invasion and nerve paralysis, whilst female gender and age<50 were predictors for good prognosis.
腺样囊性癌（ACC）是一种罕见的涎腺恶性肿瘤。我们的目的是回顾我们治疗腮腺ACC的经验，以确定预测预后的临床病理参数。
我们回顾性分析了在我院接受手术治疗的228例腮腺癌患者。本研究纳入了44例ACC患者。构建多变量分析风险模型以预测无复发生存概率（RFP）、无远处复发生存概率（DRFP）、总生存期（OS）和无病生存期（DFS）。
21例患者（47.7%）死于ACC，2.3%死于其他原因。41%出现局部区域复发，区域RFP率为93%，34%报告有远处转移（DM）。5年和10年总生存率分别为74%和50%。
复发主要受神经周围浸润和神经麻痹的影响，而女性和年龄<50岁是预后良好的预测因素。
