Trujillo J M, Cork A, Ahearn M J, Youness E L, McCredie K B
Blood. 1979 Apr;53(4):695-706.
Cytogenetic studies were performed in 546 patients with acute leukemia between 1968 and 1975. Two hundred thirty-four patients were aneuploid (42.9%), and 312 patients were diploid (57.1%). Among these, 32 patients were found to exhibit similar chromosomal alterations that appeared to involve specifically chromosomes 8 and 21. Banding studies in at least 15 of these patients confirmed the presence of a translocation between these two chromosomes. The cytogenetic findings were correlated with the hematologic and clinical data. It was found that each of these individuals had a typical picture of acute granulocytic leukemia with Auer rod-positive and peroxidase-positive cells. Ultrastructurally, the patients in this group also consistently demonstrated the presence of a nuclear bleb that has been positively associated with aneuploidy in acute leukemia. Clinically, they seemed to respond better to therapy than other adult patients with acute granulocytic leukemia. It is proposed that the 8/21 translocation acute leukemia represents a definite subgroup within the general category of acute granulocytic leukemia, with an incidence of approximately 7.3%.
1968年至1975年间，对546例急性白血病患者进行了细胞遗传学研究。234例患者为非整倍体（42.9%），312例患者为二倍体（57.1%）。其中，32例患者表现出相似的染色体改变，似乎特异性地涉及8号和21号染色体。对其中至少15例患者进行的显带研究证实了这两条染色体之间存在易位。细胞遗传学结果与血液学和临床数据相关。发现这些个体均具有典型的急性粒细胞白血病表现，伴有奥氏小体阳性和过氧化物酶阳性细胞。在超微结构上，该组患者也始终表现出核泡的存在，这与急性白血病中的非整倍体呈正相关。临床上，他们似乎比其他成年急性粒细胞白血病患者对治疗的反应更好。有人提出，8/21易位急性白血病代表急性粒细胞白血病总类中的一个明确亚组，发病率约为7.3%。
