Mal'chikova L S, Speranskaia N V, Elizarova E P
Biull Eksp Biol Med. 1979 Feb;87(2):134-7.
Taurine produced no effect on the cyclic nucleotides level in the heart of intact rats but sharply inhibited the cAMP and cGMP level elevation in the rat heart occuring in stress. After atropine pretreatment of the animals no effect of taurine on the heart cGMP level was observed; its effect on the cAMP level was significantly inhibited against the background of partial beta-adrenoreceptors block. It is suggested that taurine is a nonspecific regulator of the myocardial cells sensitivity to the biologically active drugs.
牛磺酸对完整大鼠心脏中的环核苷酸水平没有影响，但能显著抑制应激状态下大鼠心脏中cAMP和cGMP水平的升高。对动物进行阿托品预处理后，未观察到牛磺酸对心脏cGMP水平有影响；在部分β-肾上腺素能受体阻断的背景下，其对cAMP水平的影响被显著抑制。提示牛磺酸是心肌细胞对生物活性药物敏感性的非特异性调节剂。
