Chatterjee Shailja
Department of Oral and Maxillofacial Pathology, MMCDSR, MM University, Ambala, Haryana, India.
J Oral Maxillofac Pathol. 2017 Jan-Apr;21(1):87-91. doi: 10.4103/jomfp.JOMFP_39_16.
Telomeres are repetitive ribonucleoprotein complexes present at ends of chromosomes. To synthesize this manuscript, a thorough literature search was done using PubMed, MEDLINE and Cochrane review for English-language literature and data available from the period of 2005-2016 were analyzed for manuscript writing. Telomeres help in maintaining the cellular health, inbuilt cellular mechanisms, metabolism and normal cell cycle. Telomerase is a specialized enzyme that possesses catalytic subunits - reverse transcriptase, Terc and dyskerin. Mutations affecting telomere or any component of telomerase enzyme result in disorders such as dyskeratosis congenita, aplastic anemia, myelodysplastic syndromes and leukemias. Thus, it is important to understand the telomere biology so as to deal with normal physiologic processes such as apoptosis, aging and senescence and tumor development.
端粒是存在于染色体末端的重复性核糖核蛋白复合体。为撰写本手稿，我们使用PubMed、MEDLINE和Cochrane综述对英文文献进行了全面的文献检索，并分析了2005年至2016年期间可得的数据以用于手稿撰写。端粒有助于维持细胞健康、内在细胞机制、新陈代谢及正常细胞周期。端粒酶是一种特殊的酶，它拥有催化亚基——逆转录酶、端粒酶RNA组分（Terc）和戴氏蛋白。影响端粒或端粒酶任何组分的突变会导致诸如先天性角化不良、再生障碍性贫血、骨髓增生异常综合征和白血病等疾病。因此，了解端粒生物学对于应对诸如细胞凋亡、衰老和衰老以及肿瘤发生等正常生理过程非常重要。
