健康与疾病中的端粒。
Telomeres in health and disease.
作者信息
Chatterjee Shailja
机构信息
Department of Oral and Maxillofacial Pathology, MMCDSR, MM University, Ambala, Haryana, India.
出版信息
J Oral Maxillofac Pathol. 2017 Jan-Apr;21(1):87-91. doi: 10.4103/jomfp.JOMFP_39_16.
Abstract
Telomeres are repetitive ribonucleoprotein complexes present at ends of chromosomes. To synthesize this manuscript, a thorough literature search was done using PubMed, MEDLINE and Cochrane review for English-language literature and data available from the period of 2005-2016 were analyzed for manuscript writing. Telomeres help in maintaining the cellular health, inbuilt cellular mechanisms, metabolism and normal cell cycle. Telomerase is a specialized enzyme that possesses catalytic subunits - reverse transcriptase, Terc and dyskerin. Mutations affecting telomere or any component of telomerase enzyme result in disorders such as dyskeratosis congenita, aplastic anemia, myelodysplastic syndromes and leukemias. Thus, it is important to understand the telomere biology so as to deal with normal physiologic processes such as apoptosis, aging and senescence and tumor development.
摘要
端粒是存在于染色体末端的重复性核糖核蛋白复合体。为撰写本手稿，我们使用PubMed、MEDLINE和Cochrane综述对英文文献进行了全面的文献检索，并分析了2005年至2016年期间可得的数据以用于手稿撰写。端粒有助于维持细胞健康、内在细胞机制、新陈代谢及正常细胞周期。端粒酶是一种特殊的酶，它拥有催化亚基——逆转录酶、端粒酶RNA组分（Terc）和戴氏蛋白。影响端粒或端粒酶任何组分的突变会导致诸如先天性角化不良、再生障碍性贫血、骨髓增生异常综合征和白血病等疾病。因此，了解端粒生物学对于应对诸如细胞凋亡、衰老和衰老以及肿瘤发生等正常生理过程非常重要。
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Telomeres in health and disease.健康与疾病中的端粒。
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Telomere shortening in leukocyte subpopulations in depression.抑郁症患者白细胞亚群中的端粒缩短
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Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability.核纤层蛋白 AΔexon9 突变导致端粒和染色质缺陷，但不导致基因组不稳定性。
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Mediterranean diet, telomere maintenance and health status among elderly.地中海饮食、端粒维持与老年人健康状况。
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Telomeres and age-related disease: how telomere biology informs clinical paradigms.端粒与年龄相关性疾病：端粒生物学如何影响临床模式。
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The role of telomeres in musculoskeletal diseases.端粒在肌肉骨骼疾病中的作用。
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Human CST promotes telomere duplex replication and general replication restart after fork stalling.人类 CST 促进端粒双链复制，并在叉停滞后促进普遍复制重启动。
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Healthy aging and disease: role for telomere biology?健康老龄化与疾病：端粒生物学的作用？
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Telomeres in cancer and ageing.端粒与癌症和衰老。
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Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration.吸烟与健康：在吸烟持续时间影响下，基于人群的大样本队列中，端粒长度与影响人类疾病、生活质量和寿命的因素之间的关联。
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