Wenzl M, Langstaedtler M, Preiss D
Pharmazeutisches Institut der Freien Universität Berlin, F.R.G.
Int J Rad Appl Instrum A. 1988;39(10):1023-7. doi: 10.1016/0883-2889(88)90135-9.
Ruthenocene amphetamine analogues have the same brain uptake as iodo-labelled amphetamines. This paper compares the organ-distribution of 103Ru labelled ruthenocene- or ferrocene-amphetamine analogues in mice and rats with the same amphetamine in which H-atoms were partly substituted by D-atoms. The uptake in the brain is increased up to 180-200% for deuterium substituted compounds. The pattern of excreted metabolites leads to the conclusion that the deuterated amphetamines are more slowly metabolised than normal (H) compounds.
钌茂基苯丙胺类似物与碘标记的苯丙胺具有相同的脑摄取量。本文比较了103Ru标记的钌茂基或二茂铁基苯丙胺类似物在小鼠和大鼠体内的器官分布情况，以及相同的苯丙胺中氢原子部分被氘原子取代后的情况。氘取代化合物在脑中的摄取量增加了180%至200%。排泄代谢物的模式表明，氘代苯丙胺的代谢速度比正常（氢）化合物慢。
