Bruzzese Vincenzo, Palermo Giuseppe, Ridola Lorenzo, Lorenzetti Roberto, Hassan Cesare, Izzo Annamaria, Zullo Angelo
Internal Medicine, Rheumatology and Gastroenterology, "Nuovo Regina Margherita" Hospital, Rome, Italy.
Angiology Unit, "Nuovo Regina Margherita" Hospital, Rome, Italy.
Ann Transl Med. 2017 Apr;5(7):158. doi: 10.21037/atm.2017.03.68.
An independent role of chronic inflammation in the atherosclerotic process in patients with inflammatory bowel diseases (IBD) has been suggested, but data are still contentious. We assessed pre-clinical atherosclerosis in the IBD patients without traditional risk factors.
In this case-control study we assessed the early atherosclerotic alterations by carotid artery intima-media thickness (CIMT) measurement in IBD patients and matched controls. The normal CIMT values were ≤0.9 mm; moderate thickness when >0.9 and ≤1.2 mm, and pre-clinical atherosclerosis when >1.2 mm. We selected a homogeneous group of IBD patients, all in ongoing biologic therapy, without any traditional risk factor for atherosclerosis as well as controls.
The study enrolled 23 consecutive patients (16 with ulcerative colitis and 7 with Crohn's disease) and 20 controls matched for age and sex. The mean of CIMT values was not statistically different between patients and controls (0.68±0.21 . 0.82±0.2 mm; P=0.4). The prevalence of moderate CIMT thickness was significantly lower in cases than in controls (8.7% . 42.8%; P=0.01; OR: 0.15, 95% CI: 0.03-0.85).
This case-control study found that the atherosclerotic process is not more apparent in IBD patients without traditional risk factors.
慢性炎症在炎症性肠病（IBD）患者动脉粥样硬化进程中的独立作用已被提出，但数据仍存在争议。我们评估了无传统危险因素的IBD患者的临床前期动脉粥样硬化情况。
在这项病例对照研究中，我们通过测量IBD患者和匹配对照的颈动脉内膜中层厚度（CIMT）来评估早期动脉粥样硬化改变。正常CIMT值≤0.9毫米；厚度>0.9且≤1.2毫米为中度增厚，>1.2毫米为临床前期动脉粥样硬化。我们选择了一组均接受生物治疗、无任何动脉粥样硬化传统危险因素的IBD患者以及对照。
该研究纳入了23例连续患者（16例溃疡性结肠炎患者和7例克罗恩病患者）以及20例年龄和性别匹配的对照。患者和对照的CIMT值均值无统计学差异（0.68±0.21. 0.82±0.2毫米；P = 0.4）。病例组中度CIMT增厚的患病率显著低于对照组（8.7%. 42.8%；P = 0.01；OR：0.15，95%CI：0.03 - 0.85）。
这项病例对照研究发现，在无传统危险因素的IBD患者中，动脉粥样硬化进程并不更明显。
