al-Damluji S
Department of Endocrinology, St Bartholomew's Hospital, London.
J Endocrinol. 1988 Oct;119(1):5-14. doi: 10.1677/joe.0.1190005.
Although the data on the effects of adrenergic mechanisms on the secretion of ACTH had seemed confusing, most of the discrepancies are probably explicable on the basis of methodological differences. In the present state of knowledge, the following conclusions seem reasonable. (1) In both man and rat, activation of central alpha-1 adrenoceptors is followed by increased ACTH secretion and this mechanism is important in the control of secretion of this hormone under some physiological circumstances. (2) In man, peripheral circulating catecholamines do not stimulate ACTH secretion under physiological conditions. This conclusion probably also applies to the anterior pituitary corticotrophs of the rat. (3) In the rat, beta-2 adrenoceptor agonists stimulate the intermediate lobe by a direct action that is physiologically relevant. (4) The role of central beta and alpha-2 adrenoceptors requires further investigation.
尽管关于肾上腺素能机制对促肾上腺皮质激素（ACTH）分泌影响的数据似乎令人困惑，但大多数差异可能基于方法学的不同而得到解释。就目前的知识水平而言，以下结论似乎是合理的。（1）在人和大鼠中，中枢α-1肾上腺素能受体激活后促肾上腺皮质激素分泌增加，并且在某些生理情况下，该机制在控制这种激素的分泌中很重要。（2）在人类中，生理条件下外周循环儿茶酚胺不会刺激促肾上腺皮质激素分泌。这一结论可能也适用于大鼠的垂体前叶促肾上腺皮质细胞。（3）在大鼠中，β-2肾上腺素能受体激动剂通过一种生理相关的直接作用刺激中间叶。（4）中枢β和α-2肾上腺素能受体的作用需要进一步研究。
