应激后皮质醇水平升高与 ADHD 儿童反应时变异性相关。
Increased cortisol after stress is associated with variability in response time in ADHD children.
机构信息
Department of Psychiatry, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Yonsei Med J. 2010 Mar;51(2):206-11. doi: 10.3349/ymj.2010.51.2.206. Epub 2010 Feb 12.
PURPOSE
Children with attention-deficit/hyperactivity disorder (ADHD) often perform poorly during cognitive tests. We sought to evaluate cortisol as potential moderator of performance in mentally challenging tasks in children with ADHD.
MATERIALS AND METHODS
Ninety clinic-referred children with ADHD were studied. Cortisol contents in saliva were measured before and after administration of a continuous performance test (CPT).
RESULTS
Pre and post CPT cortisol levels were similar in 68 children. Children whose cortisol level increased after testing ( n = 22 ) displayed a significantly longer response time and increased response time variability scores as compared to children who did not display increase of cortisol after the CPT test. Even after controlling for the effects of response time and anxiety, the changes in cortisol levels were associated with effect on response time variability.
CONCLUSION
The patients who showed an increased cortisol level after stress displayed a higher variability in response time than the patients who showed no change or a decreased cortisol level. The result of the current study suggests that stress-induced high norepinephrine (NE) release may accompany poorer attention performance in patients with ADHD.
目的
患有注意缺陷多动障碍（ADHD）的儿童在认知测试中表现通常较差。我们试图评估皮质醇作为 ADHD 儿童在心理挑战性任务中表现的潜在调节剂。
材料和方法
研究了 90 名临床推荐的 ADHD 儿童。在进行连续性能测试（CPT）前后测量唾液中的皮质醇含量。
结果
68 名儿童的 CPT 前后皮质醇水平相似。与 CPT 测试后皮质醇水平未升高的儿童相比，皮质醇水平升高的 22 名儿童的反应时间明显延长，反应时变异性评分增加。即使在控制反应时间和焦虑的影响后，皮质醇水平的变化也与反应时变异性的影响有关。
结论
应激后皮质醇水平升高的患者的反应时变异性高于皮质醇水平无变化或降低的患者。本研究的结果表明，应激诱导的去甲肾上腺素（NE）释放增加可能伴随着 ADHD 患者注意力表现较差。
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