Thornadtsson Alexandra, Drca Nikola, Ricciardolo Fabio, Högman Marieann
a Department of Medical Sciences , Respiratory, Allergy and Sleep Research, Uppsala University , Uppsala , Sweden.
b Centre for Research and Development, Uppsala University/Region Gävleborg , Sweden.
Ups J Med Sci. 2017 Jun;122(2):85-91. doi: 10.1080/03009734.2017.1317886. Epub 2017 May 8.
The objective of this study was to apply extended NO analysis for measurements of NO dynamics in the lung, divided into alveolar and airway contribution, in amateur runners and marathoners.
The athletes participated in either a marathon or a half marathon. The athletes self-reported their age, weight, height, training distance per week, competing distance, cardio-pulmonary health, atopic status, and use of tobacco. Measurements of exhaled NO (FNO) with estimation of alveolar NO (CNO) and airway flux (JNO), ventilation, pulse oximetry, and peak flow were performed before, immediately after, and 1 hour after completing the race.
At baseline the alveolar NO was higher in amateur runners, 2.9 ± 1.1 ppb (p = 0.041), and marathoners, 3.6 ± 1.9 ppb (p = 0.002), than in control subjects, 1.4 ± 0.5 ppb. JNO was higher in marathoners, 0.90 ± 0.02 nL s (p = 0.044), compared with controls, 0.36 ± 0.02 nL s, whereas the increase in amateur runners, 0.56 ± 0.02 nL s, did not attain statistical significance (p = 0.165). Immediately after the race there was a decrease in FNO in both amateur runners and marathoners, whereas CNO and JNO were decreased in marathoners only.
Our results support the view that there is an adaptation of the lung to exercise. Thus strenuous exercise increased both airway and alveolar NO, and this might in turn facilitate oxygen uptake.
本研究的目的是应用扩展的一氧化氮（NO）分析方法，测量业余跑步者和马拉松运动员肺部的NO动态变化，并区分肺泡和气道的贡献。
运动员参加马拉松或半程马拉松比赛。运动员自行报告其年龄、体重、身高、每周训练距离、比赛距离、心肺健康状况、特应性状态和烟草使用情况。在比赛前、比赛结束后立即以及比赛结束后1小时，进行呼出NO（FNO）测量，同时估算肺泡NO（CNO）和气道通量（JNO）、通气量、脉搏血氧饱和度和峰值流量。
在基线时，业余跑步者的肺泡NO较高，为2.9±1.1 ppb（p = 0.041），马拉松运动员为3.6±1.9 ppb（p = 0.002），均高于对照组的1.4±0.5 ppb。马拉松运动员的JNO较高，为0.90±0.02 nL·s（p = 0.044），而对照组为0.36±0.02 nL·s，业余跑步者增加至0.56±0.02 nL·s，但未达到统计学显著性（p = 0.165）。比赛结束后立即，业余跑步者和马拉松运动员的FNO均下降，而仅马拉松运动员的CNO和JNO下降。
我们的结果支持肺部适应运动的观点。因此，剧烈运动增加了气道和肺泡的NO，这可能反过来促进氧气摄取。
