Abdel Moneim Ahmed Esmat, Guerra-Librero Ana, Florido Javier, Shen Ying-Qiang, Fernández-Gil Beatriz, Acuña-Castroviejo Darío, Escames Germaine
Department of Zoology and Entomology, Faculty of Science, Helwan University, 11795 Cairo, Egypt.
Centro de Investigación Biomédica, Universidad de Granada, 18016 Granada, Spain.
Int J Mol Sci. 2017 May 7;18(5):1003. doi: 10.3390/ijms18051003.
The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, the role of melatonin in the treatment of mucositis has recently been investigated, and offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients' lives.
目前治疗头颈部癌症的方法包括放疗和/或化疗。不幸的是，癌症治疗可能会导致局部和全身并发症，如口腔炎，这是口腔和胃肠道中最常见的剂量依赖性并发症。口腔炎会使已经身心疲惫的癌症患者的生活质量大幅下降。然而，褪黑素在口腔炎治疗中的作用最近已得到研究，并为预防和/或管理放疗和/或化疗引起的口腔炎提供了一种有效的替代疗法。本综述着重于口腔炎的病理生物学和管理，以提高癌症患者的生活质量。
