Schneider A, Kirchmayr R, De Villiers E M, Gissmann L
Department of Gynecology and Obstetrics, University of Ulm, West Germany.
J Urol. 1988 Dec;140(6):1431-4. doi: 10.1016/s0022-5347(17)42065-9.
The male sexual partners of 156 women with human papillomavirus infection of the cervix uteri were examined. In 120 men (77 per cent) penile lesions were found on examination of the penis via a colposcope (peniscopy) the most common of which were flat acetowhite lesions (53 per cent). Predilection sites of lesions were the urethral meatus and the corona glandis (23 and 19 per cent of the lesions, respectively). Using filter in situ hybridization human papillomavirus-deoxyribonucleic acid was found in penile smears of 61 men (39 per cent). The cancer-associated viral types (human papillomavirus 16 and 18) were identified in 75 per cent of the human papillomavirus positive men. Viral types of sexual partners were identical in 87 per cent. The correlation between infections with human papillomavirus 16 and 18, and the severity of the cervical lesion was significant in corresponding sexual partners. Our results support the hypothesis that male sexual partners represent a risk factor by acting as a reservoir for genital infections with papillomaviruses. The majority of human papillomavirus infections are of subclinical character. They require sensitive diagnostic techniques, such as peniscopy and hybridization for their identification. Detection and treatment of subclinical human papillomavirus infection in men may be important for the prevention of genital cancer in women.
对156名子宫颈人乳头瘤病毒感染女性的男性性伴侣进行了检查。通过阴道镜（阴茎镜检查）检查阴茎，在120名男性（77%）中发现了阴茎病变，其中最常见的是扁平醋酸白病变（53%）。病变的好发部位是尿道口和冠状沟（分别占病变的23%和19%）。使用滤膜原位杂交法，在61名男性（39%）的阴茎涂片样本中发现了人乳头瘤病毒脱氧核糖核酸。在人乳头瘤病毒阳性男性中，75%检测出与癌症相关的病毒类型（人乳头瘤病毒16型和18型）。性伴侣的病毒类型87%相同。在相应的性伴侣中，人乳头瘤病毒16型和18型感染与宫颈病变的严重程度之间存在显著相关性。我们的结果支持这样一种假设，即男性性伴侣作为乳头瘤病毒生殖器感染的储存库，是一个危险因素。大多数人乳头瘤病毒感染具有亚临床特征。它们需要灵敏的诊断技术，如阴茎镜检查和杂交技术来进行识别。男性亚临床人乳头瘤病毒感染的检测和治疗对于预防女性生殖器癌症可能很重要。
