Argueta-Figueroa Liliana, Martínez-Alvarez O, Santos-Cruz J, Garcia-Contreras R, Acosta-Torres L S, de la Fuente-Hernández J, Arenas-Arrocena M C
Laboratorio de Investigación Interdisciplinaria, Área de Nanoestructuras y Biomateriales, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, 37684 Guanajuato, México.
Departamento de Ingeniería en Energía, Universidad Politécnica de Guanajuato, 38483, Guanajuato, México.
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1305-1315. doi: 10.1016/j.msec.2017.02.120. Epub 2017 Feb 27.
Metallic sulfides involve the chemical bonding of one or more sulfur atoms to a metal. Metallic sulfides are cheap, abundant semiconductor materials that can be used for several applications. However, an important and emerging use for non-toxic metallic sulfides in biomedical applications has arisen quickly in the medical field. In this systematic review, the available data from electronic databases were collected according to PRISMA alignments for systematic reviews. This review shows that these metallic sulfides could be promising for biomedical uses and applications. This systematic review is focused primarily on the following compounds: silver sulfide, copper sulfide, and iron sulfide. The aim of this review was to provide a quick reference on synthesis methods, biocompatibility, recent advances and perspectives, with remarks on future improvements. The toxicity of metallic sulfides depends directly on the cytotoxicity of their interactions with cells and tissues. Metallic sulfides have potential biomedical applications due to their antibacterial properties, uses in imaging and diagnostics, therapies such as photothermal therapy and chemotherapy in tumors and cancer cells, drug delivery and the fabrication of biosensors for the sensitive and selective detection of moieties, among others. Although current evidence about metallic sulfide NPs is promising, there are still several issues to be addressed before these NPs can be used in biomedicine. The current review is a brief but significant guide to metallic sulfides and their potential uses in the biomedical field.
金属硫化物涉及一个或多个硫原子与一种金属的化学键合。金属硫化物是廉价且丰富的半导体材料，可用于多种应用。然而，无毒金属硫化物在生物医学应用中的一种重要且新兴的用途在医学领域迅速兴起。在本系统评价中，根据系统评价的PRISMA准则收集了电子数据库中的可用数据。该评价表明，这些金属硫化物在生物医学用途和应用方面可能很有前景。本系统评价主要关注以下化合物：硫化银、硫化铜和硫化铁。本评价的目的是提供关于合成方法、生物相容性、最新进展和前景的快速参考，并对未来的改进提出意见。金属硫化物的毒性直接取决于它们与细胞和组织相互作用的细胞毒性。金属硫化物因其抗菌特性、在成像和诊断中的应用、在肿瘤和癌细胞中的光热疗法和化疗等治疗方法、药物递送以及用于敏感和选择性检测部分的生物传感器的制造等，而具有潜在的生物医学应用。尽管目前关于金属硫化物纳米颗粒的证据很有前景，但在这些纳米颗粒可用于生物医学之前，仍有几个问题需要解决。当前的评价是对金属硫化物及其在生物医学领域潜在用途的简要但重要的指南。
