垂体切除大鼠应激诱导的免疫改变。
Stress-induced alterations of immunity in hypophysectomized rats.
作者信息
Keller S E, Schleifer S J, Liotta A S, Bond R N, Farhoody N, Stein M
机构信息
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
出版信息
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9297-301. doi: 10.1073/pnas.85.23.9297.
Abstract
Stress-induced suppression of mitogen-induced lymphocyte proliferation was demonstrated in hypophysectomized rats. Stress effects on the numbers of peripheral blood lymphocytes and lymphocyte subsets and on splenic natural killer cell activity require the presence of pituitary. A pituitary-dependent restraining influence on stress-induced alteration of immunity is described. These results indicate that stress-induced modulation of immunity is complex and includes a range of enhancing and inhibitory mechanisms.
摘要
在垂体切除的大鼠中证实了应激诱导的丝裂原诱导淋巴细胞增殖的抑制作用。应激对外周血淋巴细胞数量、淋巴细胞亚群以及脾自然杀伤细胞活性的影响需要垂体的存在。描述了垂体依赖性对应激诱导的免疫改变的抑制作用。这些结果表明，应激诱导的免疫调节是复杂的，包括一系列增强和抑制机制。
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