下丘脑-免疫相互作用：通过损毁下丘脑前部对自然杀伤活性的神经调节。
Hypothalamic-immune interactions: neuromodulation of natural killer activity by lesioning of the anterior hypothalamus.
作者信息
Cross R J, Markesbery W R, Brooks W H, Roszman T L
出版信息
Immunology. 1984 Feb;51(2):399-405.
Placement of bilateral electrolytic lesions in the preoptic-anterior hypothalamic area (AHT) of Fischer 344 rats results in decreased splenic NK activity as compared to control and normal animals. Animals with AHT lesions have a decrease in NK activity 4 and 7 days after lesion placement, with a return to normal activity by day 14. Fractionation of spleen cells on glass bead columns results in nonadherent and adherent cell fractions with NK activity. AHT lesions affect NK activity only in the adherent cell fraction. The removal of macrophages from this cell fraction did not restore NK activity. Moreover, this NK activity is not the result of cytotoxic macrophages. Hypophysectomy decreases NK activity in lesioned and non-lesioned animals, suggesting the influence of pituitary factors. These data indicate that the anterior hypothalamus is capable of modulating the cytotoxic activity of NK cells. Thus, neuroimmunomodulation may be a potential factor in susceptibility to some disease states such as viral infections and neoplasia.
在Fischer 344大鼠的视前区-下丘脑前部区域（AHT）进行双侧电解损伤，与对照动物和正常动物相比，会导致脾脏自然杀伤细胞（NK）活性降低。AHT损伤的动物在损伤后第4天和第7天NK活性降低，到第14天恢复正常活性。通过玻璃珠柱对脾细胞进行分离，可得到具有NK活性的非黏附细胞组分和黏附细胞组分。AHT损伤仅影响黏附细胞组分中的NK活性。从该细胞组分中去除巨噬细胞并不能恢复NK活性。此外，这种NK活性并非细胞毒性巨噬细胞所致。垂体切除术会降低损伤动物和未损伤动物的NK活性，提示垂体因子的影响。这些数据表明，下丘脑前部能够调节NK细胞的细胞毒性活性。因此，神经免疫调节可能是某些疾病状态（如病毒感染和肿瘤形成）易感性的一个潜在因素。
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