King Madeline, Heil Emily, Kuriakose Safia, Bias Tiffany, Huang Vanthida, El-Beyrouty Claudine, McCoy Dorothy, Hiles Jon, Richards Lynette, Gardner Julianne, Harrington Nicole, Biason Kenneth, Gallagher Jason C
Philadelphia College of Pharmacy, Philadelphia, Pennsylvania, USA.
University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00449-17. Print 2017 Jul.
Ceftazidime-avibactam is a novel cephalosporin-beta-lactamase inhibitor combination that is active against many carbapenem-resistant (CRE). We describe a retrospective chart review for 60 patients who received ceftazidime-avibactam for a CRE infection. In-hospital mortality was 32%, 53% of patients had microbiological cure, and 65% had clinical success. In this severely ill population with CRE infections, ceftazidime-avibactam was an appropriate option.
头孢他啶-阿维巴坦是一种新型的头孢菌素-β-内酰胺酶抑制剂组合,对多种耐碳青霉烯类肠杆菌科细菌(CRE)具有活性。我们对60例接受头孢他啶-阿维巴坦治疗CRE感染的患者进行了回顾性病历审查。住院死亡率为32%,53%的患者实现了微生物学治愈,65%的患者取得了临床成功。在这群患有CRE感染的重症患者中,头孢他啶-阿维巴坦是一个合适的选择。