Ball Alyssa S, Chaparian Ryan R, van Kessel Julia C
Department of Biology, Indiana University, Bloomington, Indiana, USA.
Department of Biology, Indiana University, Bloomington, Indiana, USA
J Bacteriol. 2017 Sep 5;199(19). doi: 10.1128/JB.00105-17. Print 2017 Oct 1.
The coordination of group behaviors in bacteria is accomplished via the cell-cell signaling process called quorum sensing. Vibrios have historically been models for studying bacterial communication due to the diverse and remarkable behaviors controlled by quorum sensing in these bacteria, including bioluminescence, type III and type VI secretion, biofilm formation, and motility. Here, we discuss the LuxR/HapR family of proteins, the master global transcription factors that direct downstream gene expression in response to changes in cell density. These proteins are structurally similar to TetR transcription factors but exhibit distinct biochemical and genetic features from TetR that determine their regulatory influence on the quorum sensing gene network. We review here the gene groups regulated by LuxR/HapR and quorum sensing and explore the targets that are common and unique among species.
细菌中群体行为的协调是通过称为群体感应的细胞间信号传导过程来实现的。由于群体感应控制着这些细菌中多样且显著的行为，包括生物发光、III型和VI型分泌、生物膜形成以及运动性，弧菌一直是研究细菌通讯的模型。在此，我们讨论LuxR/HapR蛋白家族，这是一类主要的全局转录因子，它们会根据细胞密度的变化来指导下游基因表达。这些蛋白在结构上与TetR转录因子相似，但具有与TetR不同的生化和遗传特征，这些特征决定了它们对群体感应基因网络的调控影响。我们在此回顾由LuxR/HapR和群体感应调控的基因组，并探索不同物种之间共有的和独特的靶点。
