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[内源性RNA病毒元件在RNA病毒感染中的可能作用]

[Possible roles of endogenous RNA virus elements in RNA virus infection].

作者信息

Komiya Nobuhiro

机构信息

Japanese Red Cross Wakayama medical center Department of Infectious Diseases.

出版信息

Uirusu. 2016;66(1):47-52. doi: 10.2222/jsv.66.47.

DOI:10.2222/jsv.66.47
PMID:28484178
Abstract

While ebola virus disease (EVD) outbreak in West Africa seemed to be subsided, there are still some sporadic cases reported from the field. Many studies were conducted during the outbreak. It was identified that the virus can survive for a long period in certain areas of the survivors and they can be a reservoir. But the mechanism is still unknown. Currently no specific drug for EVD is established and classic supportive therapy was the mainstay of the treatment. A new ebola vaccine candidates appear to be highly effective for post-exposure prophylaxis. Rapid diagnostic tests are under development. In West Africa, Ebola response and recovery efforts to achieve and to sustain a "resilient zero" are ongoing. The situation in the communities is stabilized but ebola survivors are still suffering both from stigma and sequelae.EVD outbreak damaged affected countries' health, economic and education systems. The risk of re-outbreak is still remained. It is important to strengthen comprehensive public health system to prevent the future emerging disease outbreaks.

摘要

虽然西非的埃博拉病毒病(EVD)疫情似乎已得到控制,但仍有一些零星病例从疫区传来。疫情期间开展了许多研究。已确定该病毒可在幸存者的某些部位长期存活,他们可能成为病毒宿主。但具体机制仍不清楚。目前尚未研制出针对埃博拉病毒病的特效药物,经典的支持性疗法仍是主要治疗手段。一种新的埃博拉候选疫苗似乎对暴露后预防非常有效。快速诊断测试正在研发中。在西非,为实现并维持“弹性零病例”而进行的埃博拉应对和恢复工作仍在继续。社区局势已稳定,但埃博拉幸存者仍遭受着污名化和后遗症的折磨。埃博拉病毒病疫情破坏了受影响国家的卫生、经济和教育系统。再次爆发疫情的风险依然存在。加强综合公共卫生系统对于预防未来新出现的疾病疫情至关重要。

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