Baljic Rusmir, Konjo Hadzan, Hrustemovic Dzenana, Gazibera Belma, Katica Amela, Hukic Mirsada
Clinic for Infectious Disease, Clinical Center University of Sarajevo, Bosnia-Herzegovina.
Clinic for Orthopedics and Traumatology, Clinical Center University of Sarajevo, Bosnia-Herzegovina.
Mater Sociomed. 2017 Mar;29(1):14-16. doi: 10.5455/msm.2017.29.14-16.
To investigate possible prognostic values of CD4+, CD8+ T-lymphocytes, CD4/CD8 ratio to clinical course of chickenpox in immunocompetent hosts.
We performed a prospective study which included 69 immunocompetent patients with chickenpox who were addmited to Clinic for infectious disease, Clinical Center University of Sarajevo, in a 18 month period. All patients were divided into two groups depending on clinical presentation on admission. Patients with mild clinical form were dedicated to "outpatient" group, and patients with moderate, severe or life-threatening clinical forms were dedicated to "hospitalized" group. Also 30 healthy volunteers are included in study as a control group. We analyzed values of CD4+, CD8+ percentage, CD4/CD8 ratio with comparison to clinical course of chickenpox. All specimens were taken in acute phase of illness.
Values of CD4+ percentage were significantly declined in a group of hospitalized patients, compared to group of outpatients and control group. Values of CD8+ percentage were higher in a group of hospitalized patients, while CD4/CD8 values were lower in comparison to a group of outpatients and control group.
We found significant correlation between these parameters and clinical course of chickenpox.
探讨免疫功能正常宿主中CD4⁺、CD8⁺ T淋巴细胞及CD4/CD8比值对水痘临床病程的可能预后价值。
我们进行了一项前瞻性研究，在18个月期间纳入了69例免疫功能正常的水痘患者，这些患者均被收治于萨拉热窝大学临床中心传染病诊所。所有患者根据入院时的临床表现分为两组。临床表现为轻症的患者被归入“门诊”组，临床表现为中度、重度或危及生命的患者被归入“住院”组。此外，30名健康志愿者作为对照组纳入研究。我们分析了CD4⁺、CD8⁺百分比及CD4/CD8比值与水痘临床病程的关系。所有标本均在疾病急性期采集。
与门诊组和对照组相比，住院组患者的CD4⁺百分比值显著下降。住院组患者的CD8⁺百分比值较高，而与门诊组和对照组相比，CD4/CD8值较低。
我们发现这些参数与水痘临床病程之间存在显著相关性。
