Lv Xinrui, Kong Jing, Chen Wei-Dong, Wang Yan-Dong
Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Medicine, Henan UniversityKaifeng, China.
Key Laboratory of Molecular Pathology, School of Basic Medical Science, Inner Mongolia Medical UniversityHohhot, China.
Front Pharmacol. 2017 Apr 24;8:221. doi: 10.3389/fphar.2017.00221. eCollection 2017.
Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues. It has been shown that the apelin/APJ system plays various roles in physiology and pathophysiology of many organs. It regulates cardiovascular development or cardiac disease, glycometabolism and fat metabolism as well as metabolic disease. The apelin/APJ system participates in various cell activities such as proliferation, migration, apoptosis or inflammation. However, apelin/APJ function in the liver is still under investigation. In the liver, the apelin-APJ system could play an inhibitory role in liver regeneration and promote Fas-induced apoptosis. It may participate in the formation of hepatic fibrosis or cirrhosis, and even cancer. In this review, we summarize the role of the apelin/APJ system in liver disease.
阿片肽是一种内源性肽，是APJ受体（血管紧张素II受体样1，AT-1）的配体。阿片肽/APJ系统分布于多种外周器官组织。研究表明，阿片肽/APJ系统在许多器官的生理和病理生理过程中发挥着多种作用。它调节心血管发育或心脏疾病、糖代谢和脂肪代谢以及代谢性疾病。阿片肽/APJ系统参与各种细胞活动，如增殖、迁移、凋亡或炎症。然而，阿片肽/APJ在肝脏中的功能仍在研究中。在肝脏中，阿片肽-APJ系统可能在肝再生中起抑制作用，并促进Fas诱导的凋亡。它可能参与肝纤维化或肝硬化甚至癌症的形成。在这篇综述中，我们总结了阿片肽/APJ系统在肝脏疾病中的作用。
