白细胞介素-6信号通路及其在肾脏疾病中的作用：最新进展
Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update.
作者信息
Su Hua, Lei Chun-Tao, Zhang Chun
机构信息
Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Front Immunol. 2017 Apr 21;8:405. doi: 10.3389/fimmu.2017.00405. eCollection 2017.
Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.
摘要
白细胞介素-6（IL-6）是一种多效性细胞因子，不仅调节免疫和炎症反应，还影响造血、代谢和器官发育。IL-6 可同时引发不同甚至相互矛盾的生理病理过程，这可能通过经典和转信号等信号通路级联来区分。除了发挥多种重要的生理作用外，IL-6 失调已被证明是多种自身免疫性和炎症性疾病、代谢异常及恶性肿瘤的基础。本综述概述了 IL-6 信号通路的基本概念以及 IL-6 与肾固有细胞（包括足细胞、系膜细胞、内皮细胞和肾小管上皮细胞）之间的相互作用。此外，我们总结了 IL-6 在几种肾脏疾病中的作用，如 IgA 肾病、狼疮性肾炎、糖尿病肾病、急性肾损伤和慢性肾脏病。
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