Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 830 North University Ave, Ann Arbor, MI, 48109, USA.
Institute of Brain Science, the State Key Laboratory of Medical Neurobiology and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China.
Neurosci Bull. 2018 Feb;34(1):186-193. doi: 10.1007/s12264-017-0136-z. Epub 2017 May 8.
In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch. We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli, a hallmark symptom for many chronic pain or itch patients.
1905 年，亨利·黑德（Henry Head）首次提出，与疼痛相关的原发性感觉信息的传递可以通过无害触觉和温度感觉传入的输入进行负调节。1965 年，梅尔扎克（Melzak）和沃尔（Wall）提出了更为具体的疼痛门控理论，强调了无髓 C 纤维和有髓 A 纤维在疼痛传递中的相互作用。在这里，我们回顾了目前对传递和门控机械性疼痛或瘙痒的脊髓微循环的理解。我们还讨论了门控的中断如何导致对无害机械刺激引起的疼痛或瘙痒，这是许多慢性疼痛或瘙痒患者的一个标志性症状。
