硬皮病血清对人微血管内皮细胞的影响。抗体依赖性细胞毒性的诱导。
The effects of scleroderma serum on human microvascular endothelial cells. Induction of antibody-dependent cellular cytotoxicity.
作者信息
Marks R M, Czerniecki M, Andrews B S, Penny R
机构信息
Centre for Immunology, University of New South Wales, Sydney, Australia.
出版信息
Arthritis Rheum. 1988 Dec;31(12):1524-34. doi: 10.1002/art.1780311209.
To investigate the vascular immunopathology of systemic sclerosis, we developed a model consisting of human microvascular endothelial cells, leukocytes, and serum. Sera from 19% of the patients studied mediated antibody-dependent cellular cytotoxicity against endothelial cells. Some sera also mediated cytotoxicity against aortic endothelium and fibroblasts. K lymphocytes, the cells that mediate antibody-dependent cellular cytotoxicity, were identified in the skin of some patients. The sera alone were not cytotoxic or growth inhibitory, and did not affect endothelial prostacyclin production.
为研究系统性硬化症的血管免疫病理学，我们建立了一个由人微血管内皮细胞、白细胞和血清组成的模型。在所研究患者中，19%的患者血清介导了针对内皮细胞的抗体依赖性细胞毒性作用。一些血清还介导了针对主动脉内皮细胞和成纤维细胞的细胞毒性作用。在一些患者的皮肤中鉴定出了介导抗体依赖性细胞毒性作用的K淋巴细胞。单独的血清没有细胞毒性或生长抑制作用，也不影响内皮细胞前列环素的产生。
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