Drenk F, Deicher H R
Abt. Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, FRG.
J Rheumatol. 1988 Mar;15(3):468-74.
Endothelial cytotoxic activity prepared from sera of patients with progressive systemic sclerosis (PSS) causes changes in endothelial cell physiology in vitro and in vivo. In the presence of endothelial cytotoxic activity human endothelial cell migration and fibronectin production in vitro were strongly reduced. Repeated intravenous injection of 1 ml partially purified endothelial cytotoxic activity IV once a week into rabbits caused a significant increase of serum FVIIIR: Ag, changes in endothelial cells morphology, and generalized dilatation of capillaries. Taken together, these results support the hypothesis that endothelial cytotoxic activity is a slow acting material which may initiate the obliterative vasculopathy in PSS by chronic damage of endothelial cells.
从进行性系统性硬化症（PSS）患者血清中制备的内皮细胞毒性活性，在体外和体内均可引起内皮细胞生理变化。在内皮细胞毒性活性存在的情况下，人内皮细胞在体外的迁移和纤连蛋白生成显著减少。每周一次给兔子静脉注射1毫升部分纯化的内皮细胞毒性活性物质IV，可导致血清FVIIIR:Ag显著增加、内皮细胞形态改变以及毛细血管普遍扩张。综上所述，这些结果支持以下假说：内皮细胞毒性活性是一种作用缓慢的物质，可能通过对内皮细胞的慢性损伤引发PSS中的闭塞性血管病。
