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BODIPY-Au(I):用于单线态氧生成和光动力疗法的光敏剂。

BODIPY-Au(I): A Photosensitizer for Singlet Oxygen Generation and Photodynamic Therapy.

机构信息

Department of Chemistry, Faculty of Science, İzmir Institute of Technology , Urla, 35430 Izmir, Turkey.

出版信息

Org Lett. 2017 May 19;19(10):2522-2525. doi: 10.1021/acs.orglett.7b00791. Epub 2017 May 9.

DOI:10.1021/acs.orglett.7b00791
PMID:28485948
Abstract

Upon complexation with Au(I), a photoinactive BODIPY derivative was transformed into a highly photoactive triplet sensitizer. Along with high efficiency in singlet oxygen generation (Φ = 0.84), the new BODIPY-Au(I) skeleton showed excellent photocytotoxic activity against cancer cell lines (EC = 2.5 nM).

摘要

与金(I)络合后,一种非光活性的 BODIPY 衍生物转变成了一种高活性的三重态敏化剂。新的 BODIPY-Au(I) 骨架不仅具有高效的单线态氧生成效率(Φ = 0.84),还对癌细胞系表现出优异的光细胞毒性活性(EC = 2.5 nM)。

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